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Title: | Distinct monocyte subset phenotypes in patients with different clinical forms of chronic Chagas disease and seronegative dilated cardiomyopathy | Authors: | Pérez-Mazliah, Damián E Castro Eiro, Melisa D Alvarez, María Gabriela Lococo, Bruno Bertocchi, Graciela Cesar, Gonzalo Natale, María Ailén Albareda, María Cecilia Viotti, Rodolfo Laucella, Susana A. |
Keywords: | Adulto;Anciano;Anticuerpos Antiprotozoarios;Cardiomiopatía Dilatada;Enfermedad de Chagas;Citometría de Flujo;Proteínas Ligadas a GPI;Humanos;Inmunofenotipificación;Receptores de Lipopolisacáridos;Persona de Mediana Edad;Monocitos;Receptores de IgG;Trypanosoma cruzi;Adulto Joven;Fenotipo | Issue Date: | 22-Oct-2018 | Journal: | PLoS neglected tropical diseases | Abstract: | Chronic infection with Trypanosoma cruzi leads to a constant stimulation of the host immune system. Monocytes, which are recruited in response to inflammatory signals, are divided into classical CD14hiCD16-, non-classical CD14loCD16+ and intermediate CD14hiCD16+ subsets. In this study, we evaluated the frequencies of monocyte subsets in the different clinical stages of chronic Chagas disease in comparison with the monocyte profile of seronegative heart failure subjects and seronegative healthy controls. The effect of the anti-parasite drug therapy benznidazole on monocyte subsets was also explored. |
Description: | Fil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Álvarez, María Gabriela. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: Bertocchi, Graciela. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: César, Gonzalo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Natale, María A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Albareda, María C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1686 | DOI: | 10.1371/journal.pntd.0006887 | Rights: | Open Access |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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pntd.0006887.pdf | Artículo en inglés | 1.62 MB | Adobe PDF | View/Open |
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