Use este identificador para citar ou linkar para este item:
http://sgc.anlis.gob.ar/handle/123456789/1484
Título: | Allopurinol reduces antigen-specific and polyclonal activation of human T cells | Autor(es): | Pérez-Mazliah, Damián E Albareda, María Cecilia Alvarez, María G Lococo, Bruno Bertocchi, Graciela Luciana Petti, Marcos Viotti, Rodolfo Laucella, Susana A. |
Palavras-chave: | Antiinflamatorios;Linfocitos T;Th1 cytokines;Alopurinol;Xantina Oxidasa | Data do documento: | 2012 | Jornal: | Frontiers in immunology | Resumo: | Allopurinol is the most popular commercially available xanthine oxidase inhibitor and it is widely used for treatment of symptomatic hyperuricaemia, or gout. Although, several anti-inflammatory actions of allopurinol have been demonstrated in vivo and in vitro, there have been few studies on the action of allopurinol on T cells. In the current study, we have assessed the effect of allopurinol on antigen-specific and mitogen-driven activation and cytokine production in human T cells. Allopurinol markedly decreased the frequency of IFN-γ and IL-2-producing T cells, either after polyclonal or antigen-specific stimulation with Herpes Simplex virus 1, Influenza (Flu) virus, tetanus toxoid and Trypanosoma cruzi-derived antigens. Allopurinol attenuated CD69 upregulation after CD3 and CD28 engagement and significantly reduced the levels of spontaneous and mitogen-induced intracellular reactive oxygen species in T cells. The diminished T cell activation and cytokine production in the presence of allopurinol support a direct action of allopurinol on human T cells, offering a potential pharmacological tool for the management of cell-mediated inflammatory diseases. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1484 | DOI: | 10.3389/fimmu.2012.00295 |
Aparece nas Coleções: | Publicaciones INP |
Arquivos neste item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
fimmu-03-00295.pdf | Artículo en inglés | 1.75 MB | Adobe PDF | Ver/Aberto |
Visualização de página
35
Checado em 24/04/2024
Download(s)
7
Checado em 24/04/2024
Google ScholarTM
Checar
Altmetric
Altmetric
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.