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Title: | Allopurinol reduces antigen-specific and polyclonal activation of human T cells | Authors: | Pérez-Mazliah, Damián E Albareda, María Cecilia Alvarez, María G Lococo, Bruno Bertocchi, Graciela Luciana Petti, Marcos Viotti, Rodolfo Laucella, Susana A. |
Keywords: | Antiinflamatorios;Linfocitos T;Th1 cytokines;Alopurinol;Xantina Oxidasa | Issue Date: | 2012 | Journal: | Frontiers in immunology | Abstract: | Allopurinol is the most popular commercially available xanthine oxidase inhibitor and it is widely used for treatment of symptomatic hyperuricaemia, or gout. Although, several anti-inflammatory actions of allopurinol have been demonstrated in vivo and in vitro, there have been few studies on the action of allopurinol on T cells. In the current study, we have assessed the effect of allopurinol on antigen-specific and mitogen-driven activation and cytokine production in human T cells. Allopurinol markedly decreased the frequency of IFN-γ and IL-2-producing T cells, either after polyclonal or antigen-specific stimulation with Herpes Simplex virus 1, Influenza (Flu) virus, tetanus toxoid and Trypanosoma cruzi-derived antigens. Allopurinol attenuated CD69 upregulation after CD3 and CD28 engagement and significantly reduced the levels of spontaneous and mitogen-induced intracellular reactive oxygen species in T cells. The diminished T cell activation and cytokine production in the presence of allopurinol support a direct action of allopurinol on human T cells, offering a potential pharmacological tool for the management of cell-mediated inflammatory diseases. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1484 | DOI: | 10.3389/fimmu.2012.00295 |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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fimmu-03-00295.pdf | Artículo en inglés | 1.75 MB | Adobe PDF | View/Open |
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