Please use this identifier to cite or link to this item: http://sgc.anlis.gov.ar/handle/123456789/1484
Title: Allopurinol reduces antigen-specific and polyclonal activation of human T cells
Authors: Pérez-Mazliah, Damián E 
Albareda, María C 
Alvarez, María G 
Lococo, Bruno 
Bertocchi, Graciela L 
Petti, Marcos 
Viotti, Rodolfo J 
Laucella, Susana A. 
Keywords: Antiinflamatorios;Linfocitos T;Th1 cytokines;Alopurinol;Xantina Oxidasa
Issue Date: 2012
Journal: Frontiers in immunology 
Abstract: 
Allopurinol is the most popular commercially available xanthine oxidase inhibitor and it is widely used for treatment of symptomatic hyperuricaemia, or gout. Although, several anti-inflammatory actions of allopurinol have been demonstrated in vivo and in vitro, there have been few studies on the action of allopurinol on T cells. In the current study, we have assessed the effect of allopurinol on antigen-specific and mitogen-driven activation and cytokine production in human T cells. Allopurinol markedly decreased the frequency of IFN-γ and IL-2-producing T cells, either after polyclonal or antigen-specific stimulation with Herpes Simplex virus 1, Influenza (Flu) virus, tetanus toxoid and Trypanosoma cruzi-derived antigens. Allopurinol attenuated CD69 upregulation after CD3 and CD28 engagement and significantly reduced the levels of spontaneous and mitogen-induced intracellular reactive oxygen species in T cells. The diminished T cell activation and cytokine production in the presence of allopurinol support a direct action of allopurinol on human T cells, offering a potential pharmacological tool for the management of cell-mediated inflammatory diseases.
URI: http://sgc.anlis.gob.ar/handle/123456789/1484
DOI: 10.3389/fimmu.2012.00295
Appears in Collections:Publicaciones INP

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