Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1484
DC Field | Value | Language |
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dc.contributor.author | Pérez-Mazliah, Damián E | en_US |
dc.contributor.author | Albareda, María Cecilia | en_US |
dc.contributor.author | Alvarez, María G | en_US |
dc.contributor.author | Lococo, Bruno | en_US |
dc.contributor.author | Bertocchi, Graciela Luciana | en_US |
dc.contributor.author | Petti, Marcos | en_US |
dc.contributor.author | Viotti, Rodolfo | en_US |
dc.contributor.author | Laucella, Susana A. | en_US |
dc.date.accessioned | 2019-12-09T20:12:30Z | - |
dc.date.available | 2019-12-09T20:12:30Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1484 | - |
dc.description.abstract | Allopurinol is the most popular commercially available xanthine oxidase inhibitor and it is widely used for treatment of symptomatic hyperuricaemia, or gout. Although, several anti-inflammatory actions of allopurinol have been demonstrated in vivo and in vitro, there have been few studies on the action of allopurinol on T cells. In the current study, we have assessed the effect of allopurinol on antigen-specific and mitogen-driven activation and cytokine production in human T cells. Allopurinol markedly decreased the frequency of IFN-γ and IL-2-producing T cells, either after polyclonal or antigen-specific stimulation with Herpes Simplex virus 1, Influenza (Flu) virus, tetanus toxoid and Trypanosoma cruzi-derived antigens. Allopurinol attenuated CD69 upregulation after CD3 and CD28 engagement and significantly reduced the levels of spontaneous and mitogen-induced intracellular reactive oxygen species in T cells. The diminished T cell activation and cytokine production in the presence of allopurinol support a direct action of allopurinol on human T cells, offering a potential pharmacological tool for the management of cell-mediated inflammatory diseases. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Frontiers in immunology | en_US |
dc.subject | Antiinflamatorios | en_US |
dc.subject | Linfocitos T | en_US |
dc.subject | Th1 cytokines | en_US |
dc.subject | Alopurinol | en_US |
dc.subject | Xantina Oxidasa | en_US |
dc.title | Allopurinol reduces antigen-specific and polyclonal activation of human T cells | en_US |
dc.type | Artículo | en_US |
dc.identifier.doi | 10.3389/fimmu.2012.00295 | - |
item.openairetype | Artículo | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Parasitología (INP) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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fimmu-03-00295.pdf | Artículo en inglés | 1.75 MB | Adobe PDF | View/Open |
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