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Título : | Perturbed T cell IL-7 receptor signaling in chronic Chagas disease | Autor : | Albareda, María Cecilia Pérez-Mazliah, Damián E Natale, M Ailén Castro Eiro, Melisa D Alvarez, María G Viotti, Rodolfo Bertocchi, Graciela Lococo, Bruno Tarleton, Rick L Laucella, Susana A. |
Palabras clave : | Trypanosoma cruzi;Receptores de Citocinas;Enfermedad de Chagas | Fecha de publicación : | 15-abr-2015 | Journal: | Journal of immunology (Baltimore, Md. : 1950) | Resumen : | We have previously demonstrated that immune responses in subjects with chronic Trypanosoma cruzi infection display features common to other persistent infections with signs of T cell exhaustion. Alterations in cytokine receptor signal transduction have emerged as one of the cell-intrinsic mechanisms of T cell exhaustion. In this study, we performed an analysis of the expression of IL-7R components (CD127 and CD132) on CD4(+) and CD8(+) T cells and evaluated IL-7-dependent signaling events in patients at different clinical stages of chronic chagasic heart disease. Subjects with no signs of cardiac disease showed a decrease in CD127(+)CD132(+) cells and a reciprocal gain of CD127(-)CD132(+) in CD8(+) and CD4(+) T cells compared with either patients exhibiting heart enlargement or uninfected controls. T. cruzi infection, in vitro, was able to stimulate the downregulation of CD127 and the upregulation of CD132 on T cells. IL-7-induced phosphorylation of STAT5 as well as Bcl-2 and CD25 expression were lower in T. cruzi-infected subjects compared with uninfected controls. The serum levels of IL-7 were also increased in chronic chagasic patients. The present study highlights perturbed IL-7/IL-7R T cell signaling through STAT5 as a potential mechanism of T cell exhaustion in chronic T. cruzi infection. |
Descripción : | Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Natale, M. Ailén. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: Bertocchi, Graciela. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón; Argentina. Fil: Tarleton, Rick L. enter for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos. Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. |
URI : | http://sgc.anlis.gob.ar/handle/123456789/1463 | ISSN : | 1550-6606 | DOI: | 10.4049/jimmunol.1402202 | Derechos: | Open Access Creative Commons Attribution 4.0 International License |
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