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Title: Perturbed T cell IL-7 receptor signaling in chronic Chagas disease
Authors: Albareda, M Cecilia 
Pérez-Mazliah, Damián E 
Natale, M Ailén 
Castro Eiro, Melisa D 
Alvarez, María G 
Viotti, Rodolfo 
Bertocchi, Graciela 
Lococo, Bruno 
Tarleton, Rick L 
Laucella, Susana A. 
Issue Date: 15-Apr-2015
Journal: Journal of immunology (Baltimore, Md. : 1950) 
We have previously demonstrated that immune responses in subjects with chronic Trypanosoma cruzi infection display features common to other persistent infections with signs of T cell exhaustion. Alterations in cytokine receptor signal transduction have emerged as one of the cell-intrinsic mechanisms of T cell exhaustion. In this study, we performed an analysis of the expression of IL-7R components (CD127 and CD132) on CD4(+) and CD8(+) T cells and evaluated IL-7-dependent signaling events in patients at different clinical stages of chronic chagasic heart disease. Subjects with no signs of cardiac disease showed a decrease in CD127(+)CD132(+) cells and a reciprocal gain of CD127(-)CD132(+) in CD8(+) and CD4(+) T cells compared with either patients exhibiting heart enlargement or uninfected controls. T. cruzi infection, in vitro, was able to stimulate the downregulation of CD127 and the upregulation of CD132 on T cells. IL-7-induced phosphorylation of STAT5 as well as Bcl-2 and CD25 expression were lower in T. cruzi-infected subjects compared with uninfected controls. The serum levels of IL-7 were also increased in chronic chagasic patients. The present study highlights perturbed IL-7/IL-7R T cell signaling through STAT5 as a potential mechanism of T cell exhaustion in chronic T. cruzi infection.
DOI: 10.4049/jimmunol.1402202
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