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http://sgc.anlis.gob.ar/handle/123456789/1463
DC Field | Value | Language |
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dc.contributor.author | Albareda, María Cecilia | es |
dc.contributor.author | Pérez-Mazliah, Damián E | es |
dc.contributor.author | Natale, M Ailén | es |
dc.contributor.author | Castro Eiro, Melisa D | es |
dc.contributor.author | Alvarez, María G | es |
dc.contributor.author | Viotti, Rodolfo | es |
dc.contributor.author | Bertocchi, Graciela | es |
dc.contributor.author | Lococo, Bruno | es |
dc.contributor.author | Tarleton, Rick L | es |
dc.contributor.author | Laucella, Susana A. | es |
dc.date.accessioned | 2019-12-05T20:21:55Z | - |
dc.date.available | 2019-12-05T20:21:55Z | - |
dc.date.issued | 2015-04-15 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1463 | - |
dc.description | Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | es |
dc.description | Fil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | es |
dc.description | Fil: Natale, M. Ailén. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | es |
dc.description | Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | es |
dc.description | Fil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón; Argentina. | es |
dc.description | Fil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón; Argentina. | es |
dc.description | Fil: Bertocchi, Graciela. Hospital Interzonal General de Agudos Eva Perón; Argentina. | es |
dc.description | Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón; Argentina. | es |
dc.description | Fil: Tarleton, Rick L. enter for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos. | es |
dc.description | Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | es |
dc.description.abstract | We have previously demonstrated that immune responses in subjects with chronic Trypanosoma cruzi infection display features common to other persistent infections with signs of T cell exhaustion. Alterations in cytokine receptor signal transduction have emerged as one of the cell-intrinsic mechanisms of T cell exhaustion. In this study, we performed an analysis of the expression of IL-7R components (CD127 and CD132) on CD4(+) and CD8(+) T cells and evaluated IL-7-dependent signaling events in patients at different clinical stages of chronic chagasic heart disease. Subjects with no signs of cardiac disease showed a decrease in CD127(+)CD132(+) cells and a reciprocal gain of CD127(-)CD132(+) in CD8(+) and CD4(+) T cells compared with either patients exhibiting heart enlargement or uninfected controls. T. cruzi infection, in vitro, was able to stimulate the downregulation of CD127 and the upregulation of CD132 on T cells. IL-7-induced phosphorylation of STAT5 as well as Bcl-2 and CD25 expression were lower in T. cruzi-infected subjects compared with uninfected controls. The serum levels of IL-7 were also increased in chronic chagasic patients. The present study highlights perturbed IL-7/IL-7R T cell signaling through STAT5 as a potential mechanism of T cell exhaustion in chronic T. cruzi infection. | es |
dc.format | - | |
dc.language.iso | en | es |
dc.relation.ispartof | Journal of immunology (Baltimore, Md. : 1950) | es |
dc.rights | Open Access | - |
dc.rights | Creative Commons Attribution 4.0 International License | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Journal of immunology (Baltimore, Md.:1950) 2015;194(8):3883-3889 | - |
dc.subject | Trypanosoma cruzi | es |
dc.subject | Receptores de Citocinas | es |
dc.subject | Enfermedad de Chagas | es |
dc.title | Perturbed T cell IL-7 receptor signaling in chronic Chagas disease | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.4049/jimmunol.1402202 | - |
anlis.essnrd | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Parasitología (INP) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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Journalofimmunology(Baltimore,Md.1950)_2015_194_8_p3883-p3889.pdf | 1.07 MB | Adobe PDF | View/Open |
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