Por favor, use este identificador para citar o enlazar este ítem:
http://sgc.anlis.gob.ar/handle/123456789/1437
Título : | A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress-damage response | Autor : | Bustos, Patricia L. Volta, Bibiana J. Perrone, Alina E. Milduberger, Natalia Bua, Jacqueline |
Palabras clave : | Ciclofilina D;Apoptosis;Estrés Oxidativo | Fecha de publicación : | 2017 | Journal: | Cell death discovery | Resumen : | Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, modulated by cyclophilin D (CyPD), a crucial component of this protein complex. In Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, we have previously described that mitochondrial permeability transition occurs after oxidative stress induction in a cyclosporin A-dependent manner, a well-known cyclophilin inhibitor. In the present work, a mitochondrial parasite cyclophilin, named TcCyP22, which is homolog to the mammalian CyPD was identified. TcCyP22-overexpressing parasites showed an enhanced loss of mitochondrial membrane potential and loss of cell viability when exposed to a hydrogen peroxide stimulus compared with control parasites. Our results describe for the first time in a protozoan parasite that a mitochondrial cyclophilin is a component of the permeability transition pore and is involved in regulated cell death induced by oxidative stress. |
Descripción : | Fil: Bustos, Patricia L. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina. Fil: Volta, Bibiana J. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina. Fil: Perrone, Alina E. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina. Fil: Milduberger, Natalia. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina. Fil: Bua, Jacqueline. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina. |
URI : | http://sgc.anlis.gob.ar/handle/123456789/1437 | ISSN : | 2058-7716 | DOI: | 10.1038/cddiscovery.2016.92 |
Aparece en las colecciones: | Publicaciones INP |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
cddiscovery201692.pdf | Artículo en inglés | 1.82 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
30
comprobado en 26-abr-2024
Descarga(s)
18
comprobado en 26-abr-2024
Google ScholarTM
Consultar
Altmetric
Altmetric
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.