Please use this identifier to cite or link to this item: http://sgc.anlis.gov.ar/handle/123456789/1437
Title: A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress-damage response
Authors: Bustos, Patricia L. 
Volta, Bibiana J. 
Perrone, Alina E. 
Milduberger, Natalia 
Bua, Jacqueline 
Issue Date: 2017
Journal: Cell death discovery 
Abstract: 
Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, modulated by cyclophilin D (CyPD), a crucial component of this protein complex. In Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, we have previously described that mitochondrial permeability transition occurs after oxidative stress induction in a cyclosporin A-dependent manner, a well-known cyclophilin inhibitor. In the present work, a mitochondrial parasite cyclophilin, named TcCyP22, which is homolog to the mammalian CyPD was identified. TcCyP22-overexpressing parasites showed an enhanced loss of mitochondrial membrane potential and loss of cell viability when exposed to a hydrogen peroxide stimulus compared with control parasites. Our results describe for the first time in a protozoan parasite that a mitochondrial cyclophilin is a component of the permeability transition pore and is involved in regulated cell death induced by oxidative stress.
URI: http://sgc.anlis.gob.ar/handle/123456789/1437
ISSN: 2058-7716
DOI: 10.1038/cddiscovery.2016.92
Appears in Collections:Publicaciones INP

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