Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/532
Title: Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
Authors: Olivera, Gabriela Carina 
Albareda, María Cecilia 
Alvarez, María Gabriela 
De Rissio, Ana María 
Fichera, Laura E. 
Cooley, Gretchen 
Yachelini, Pedro 
Hrellac, Hugo A. 
Riboldi, Hilda 
Laucella, Susana A. 
Tarleton, Rick 
Postan, Miriam 
Issue Date: 2010
Description: Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-gamma ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-gamma responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.
URI: http://sgc.anlis.gob.ar/handle/123456789/532
Rights: info:eu-repo/semantics/openAccess
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