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Title: | Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients | Authors: | Albareda, María Cecilia Laucella, Susana A. Alvarez, María Gabriela Armenti, Alejandro Bertochi, Graciela Tarleton, Rick Postan, Miriam |
Keywords: | Trypanosoma cruzi;Enfermedad de Chagas;Enfermedades Parasitarias | Issue Date: | Mar-2006 | Publisher: | Oxford University Press | Journal: | International Immunology | Abstract: | We present a cross-sectional analysis of the maturation and migratory properties of the memory CD8(+) T cell compartment, in relation to the severity of heart disease in individuals with chronic Trypanosoma cruzi infection removed from endemic areas for longer than 20 years. Subjects with none or mild heart involvement were more likely to mount T. cruzi-specific memory IFN-gamma responses than subjects with more advanced cardiac disease, and the T. cruzi-specific CD8(+) T cell population was enriched in early-differentiated (CD27(+)CD28(+)) cells in responding individuals. In contrast, the frequency of CD27(+)CD28(+)CD8(+) T cells in the total memory CD8(+) T cell population decreases, as disease becomes more severe, while the proportion of fully differentiated memory (CD27(-)CD28(-)) CD8(+) T cells increases. The analysis of CCR7 expression revealed a significant increase in total effector/memory CD8(+) T cells (CD45RA(-)CCR7(-)) in subjects with mild heart disease as compared with uninfected controls. Altogether, these results are consistent with the hypothesis of a gradual clonal exhaustion in the CD8(+) T cell population, perhaps as a result of continuous antigenic stimulation by persistent parasites. |
Description: | Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Laucella, Susana A.. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Alvarez, María Gabriela. Hospital Interzonal General de Agudos Eva Perón, San Martín, Provincia de Buenos Aires; Argentina. Fil: Armenti, Alejandro. Hospital Interzonal General de Agudos Eva Perón, San Martín, Provincia de Buenos Aires; Argentina. Fil: Bertochi, Graciela. Hospital Interzonal General de Agudos Eva Perón, San Martín, Provincia de Buenos Aires; Argentina. Fil: Tarleton, Rick. Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA; Estados Unidos. Fil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/497 | ISSN: | 1460-2377 | DOI: | 10.1093/intimm/dxh387 | Rights: | Open Access Creative Commons Attribution 4.0 International License |
Appears in Collections: | Preproducción Publicaciones INP |
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File | Description | Size | Format | |
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InternationalImmunology,2006,18(3),465-471..pdf | Artículo en inglés | 238.75 kB | Adobe PDF | View/Open |
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