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Title: | First report of phaeohyphomycosis caused by Phialophora americana in a domestic cat from Argentina | Authors: | Borrás, Pablo Messina, Fernando Abrantes, Ruben Antonio Iachini, Ricardo Minatel, Leonardo Santiso, Gabriela María |
Keywords: | Phialophora americana;Identificación molecular;Feohifomicosis;Micosis | Issue Date: | 2022 | Journal: | JFMS open reports | Abstract: | A 10-year-old male neutered domestic shorthair cat from Quilmes (Province of Buenos Aires, Argentina) presented at the Infectious Diseases and Parasitology Unit with a hyperpigmented nodule of 5 cm diameter on the nasal plane with a small ulceration of more than 1 year's evolution. A scaly and hyperpigmented alopecic lesion of 3 cm in diameter was found on the lower edge of the tail. The patient was under immunosuppressive therapy with corticosteroids for lymphoplasmacytic duodenitis. Samples of the lesion present on the nasal plane were taken under a surgical procedure. In the wet mount preparations, pigmented irregular hyphae were observed. They developed dark colonies when cultured on Sabouraud medium. On micromorphology, structures compatible with Phialophora species were identified. PCR and sequencing of ITS (ITS1-5.8S-ITS2) confirmed Phialophora americana as the etiologic agent. A therapeutic scheme that included a combination of itraconazole oral solution (1.5 mg/kg PO q12h) with terbinafine (30 mg/kg PO q24h) was indicated for a period of 10 months. The patient died of complications resulting from its underlying disease. |
Description: | Fil: Borrás, Pablo. Infectious Diseases and Parasitology Unit, Panda Veterinary Clinic; Buenos Aires, Argentina Fil: Messina, Fernando. Mycology Unit, Francisco Javier Muñiz Infectious Diseases Hospital; Buenos Aires, Argentina Fil: Rubén, Abrantes. Superficial Mycoses and Mycelial Fungi Service, Mycology Department, INEI ANLIS 'Dr Carlos G Malbrán'; Buenos Aires, Argentina Fil: Iachini, Ricardo. Biochemical and Microbiological Lab, Instituto de Zoonosis 'Luis Pasteur'; Buenos Aires, Argentina Fil: Minatel, Leonardo. Veterinary Pathology, Faculty of Veterinary Sciences, University of Buenos Aires; Buenos Aires, Argentina Fil: Santiso, Gabriela. Infectious Diseases and Parasitology Unit, Panda Veterinary Clinic; Buenos Aires, Argentina |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2506 | DOI: | 10.1177/20551169221077611 |
Appears in Collections: | Artículos |
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10.1177_20551169221077611.pdf | 1.44 MB | Adobe PDF | View/Open |
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