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Title: | COVID-19 associated with disseminated histoplasmosis in a kidney transplant patient | Authors: | Maldonado, Ivana Elisiri, María Elisa Fernández-Canigia, Liliana Sánchez, Ana Victoria López, Liana Toranzo, Adriana López-Joffre, María Cecilia González-Fraga, Sol Canteros, Cristina Elena |
Keywords: | Argentina;COVID-19;Micosis | Issue Date: | 2022 | Journal: | Revista Argentina de microbiologia | Abstract: | We report a case of disseminated histoplasmosis and COVID-19 infection in a renal transplant recipient in Argentina. The patient exhibited respiratory symptoms, and a chest computed tomography scan (CT) showed multiple bilateral centrilobular opacities with a tree-in-bud pattern in both lobes. The patient was initially treated as having bacterial community-acquired pneumonia, and then tuberculosis. A month later, histoplasmosis was diagnosed, and Histoplasma capsulatum LAmB clade was isolated from sputum, skin and oral lesions. The patient was hospitalized and treatment was started with intravenous liposomal amphotericin B. During the course of the antifungal therapy the respiratory symptoms worsened, a new chest CT showed a unilateral lesion with a ground glass appearance and SARS-CoV-2 was detected in a new nasopharyngeal sample. In addition, plasma therapy was administered, and the immunosuppressive regimen was adjusted (everolimus was interrupted, mycophenolate mofetil reduced, and meprednisone increased). Finally, the patient's progress was favorable and was discharged after five days on oral itraconazole treatment for histoplasmosis. |
Description: | Fil: Maldonado, Ivana. Microbiología, Laboratorio Central-Hospital Alemán; Buenos Aires, Argentina Fil: Elisiri, María Elisa. Microbiología, Laboratorio Central-Hospital Alemán; Buenos Aires, Argentina Fil: Fernández-Canigia, Liliana. Microbiología, Laboratorio Central-Hospital Alemán; Buenos Aires, Argentina Fil: Ana Victoria Sánchez. Servicio de Infectología- Hospital Alemán; Buenos Aires, Argentina Fil: López, Liana. Servicio de Infectología- Hospital Alemán; Buenos Aires, Argentina Fil: Toranzo, Adriana I. Departamento Micología, Laboratorio Nacional de Referencia en Micología Médica-INEI-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires, Argentina Fil: López-Joffre, Cecilia. Departamento Micología, Laboratorio Nacional de Referencia en Micología Médica-INEI-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires, Argentina Fil: González-Fraga, Sol. Biología Molecular, Laboratorio Central - Hospital Alemán; Buenos Aires, Argentina Fil: Canteros, Cristina Elena. Departamento Micología, Laboratorio Nacional de Referencia en Micología Médica-INEI-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires, Argentina |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2488 | DOI: | 10.1016/j.ram.2021.10.006 |
Appears in Collections: | Artículos |
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