Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/2488
Title: COVID-19 associated with disseminated histoplasmosis in a kidney transplant patient
Authors: Maldonado, Ivana 
Elisiri, María Elisa 
Fernández-Canigia, Liliana 
Sánchez, Ana Victoria 
López, Liana 
Toranzo, Adriana 
López-Joffre, María Cecilia 
González-Fraga, Sol 
Canteros, Cristina Elena 
Keywords: Argentina;COVID-19;Micosis
Issue Date: 2022
Journal: Revista Argentina de microbiologia 
Abstract: 
We report a case of disseminated histoplasmosis and COVID-19 infection in a renal transplant recipient in Argentina. The patient exhibited respiratory symptoms, and a chest computed tomography scan (CT) showed multiple bilateral centrilobular opacities with a tree-in-bud pattern in both lobes. The patient was initially treated as having bacterial community-acquired pneumonia, and then tuberculosis. A month later, histoplasmosis was diagnosed, and Histoplasma capsulatum LAmB clade was isolated from sputum, skin and oral lesions. The patient was hospitalized and treatment was started with intravenous liposomal amphotericin B. During the course of the antifungal therapy the respiratory symptoms worsened, a new chest CT showed a unilateral lesion with a ground glass appearance and SARS-CoV-2 was detected in a new nasopharyngeal sample. In addition, plasma therapy was administered, and the immunosuppressive regimen was adjusted (everolimus was interrupted, mycophenolate mofetil reduced, and meprednisone increased). Finally, the patient's progress was favorable and was discharged after five days on oral itraconazole treatment for histoplasmosis.
Description: 
Fil: Maldonado, Ivana. Microbiología, Laboratorio Central-Hospital Alemán; Buenos Aires, Argentina

Fil: Elisiri, María Elisa. Microbiología, Laboratorio Central-Hospital Alemán; Buenos Aires, Argentina

Fil: Fernández-Canigia, Liliana. Microbiología, Laboratorio Central-Hospital Alemán; Buenos Aires, Argentina

Fil: Ana Victoria Sánchez. Servicio de Infectología- Hospital Alemán; Buenos Aires, Argentina

Fil: López, Liana. Servicio de Infectología- Hospital Alemán; Buenos Aires, Argentina

Fil: Toranzo, Adriana I. Departamento Micología, Laboratorio Nacional de Referencia en Micología Médica-INEI-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires, Argentina

Fil: López-Joffre, Cecilia. Departamento Micología, Laboratorio Nacional de Referencia en Micología Médica-INEI-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires, Argentina

Fil: González-Fraga, Sol. Biología Molecular, Laboratorio Central - Hospital Alemán; Buenos Aires, Argentina

Fil: Canteros, Cristina Elena. Departamento Micología, Laboratorio Nacional de Referencia en Micología Médica-INEI-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires, Argentina
URI: http://sgc.anlis.gob.ar/handle/123456789/2488
DOI: 10.1016/j.ram.2021.10.006
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