Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/245
Title: Use of a rapid test on umbilical cord blood to screen for Trypanosoma cruzi infection in pregnant women in Argentina, Bolivia, Honduras, and Mexico
Authors: Sosa-Estani, Sergio 
Gamboa-León, Miriam Rubi 
Del Cid-Lemus, Jaime 
Althabe, Fernando 
Alger, Jackeline 
Almendares, Olivia 
Cafferata, María L. 
Chippaux, Jean-Philippe 
Dumonteil, Eric 
Gibbons, Luz 
Padilla-Raygoza, Nicolás 
Schneider, Dominique 
Belizán, José M. 
Buekens, Pierre 
Perinatal Chagas Disease Working Group 
Keywords: Anticuerpos Antiprotozoarios;Estudios Transversales;Ensayo de Inmunoadsorción Enzimática;Sangre Fetal;Complicaciones Parasitarias del Embarazo;Juego de Reactivos para Diagnóstico;Sensibilidad y Especificidad;Trypanosoma cruzi;México;Honduras;Bolivia;Argentina;Enfermedad de Chagas
Issue Date: 2008
Description: We conducted a cross-sectional study of Chagas disease in five endemic areas in Argentina, Bolivia, Honduras, and México to estimate the prevalence of Trypanosoma cruzi–specific antibodies in pregnant women, and to assess the use of a rapid test (Chagas Stat-Pak) to screen for T. cruzi infection at the time of delivery. The prevalence of antibodies to T. cruzi measured by enzyme-linked immunosorbent assay (ELISA) in maternal blood was 5.5% (a range of 0.8–28.8% among the countries) in 2,495 women enrolled. Compared with ELISA in maternal blood samples, the Chagas Stat-Pak rapid test sensitivity and specificity in umbilical cord blood were 94.6% and 99.0%, respectively. These results show the ability for a rapid determination of the presence of T. cruzi–specific antibodies in umbilical cord blood as a pragmatic strategy to screen for infection in pregnant women.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Gamboa-León, Miriam Rubi. Universidad Autónoma de Yucatán. Laboratorio de Parasitología; México.
Fil: Del Cid-Lemus, Jaime. Intibucá. Región Sanitaria No. 10; Honduras.
Fil: Althabe, Fernando. Instituto de Efectividad Clínica y Sanitaria; Argentina.
Fil: Alger, Jackeline. Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal; Honduras.
Fil: Almendares, Olivia. Tulane University. School of Public Health and Tropical Medicine; Estados Unidos.
Fil: Cafferata, María L. Hospital de Clínicas. Unidad de Investigación Clínica y Epidemiológica Montevideo; Uruguay.
Fil: Chippaux, Jean-Philippe. L'Institut de recherche pour le développement (IRD); Bolivia.
Fil: Dumonteil, Eric. Universidad Autónoma de Yucatán. Laboratorio de Parasitología; México.
Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina.
Fil: Schneider, Dominique. L'Institut de recherche pour le développement (IRD); Bolivia.
Fil: Belizán, José M. Instituto de Efectividad Clínica y Sanitaria; Argentina.
Fil: Buekens, Pierre. Tulane University. School of Public Health and Tropical Medicine; Estados Unidos.
Fil: Padilla-Raygoza, Nicolás. Universidad de Guanajuato; México.
Fil: Perinatal Chagas Disease Working Group; Estados Unidos
URI: http://www.ajtmh.org/content/79/5/755.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/245
ISSN: 1476-1645
Rights: info:eu-repo/semantics/openAccess
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