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Title: Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study
Authors: Politis, Maria D 
Bermejo-Sánchez, Eva 
Canfield, Mark A 
Contiero, Paolo 
Cragan, Janet D 
Dastgiri, Saeed 
de Walle, Hermien E K 
Feldkamp, Marcia L 
Nance, Amy E 
Groisman, Boris 
Gatt, Miriam 
Benavides-Lara, Adriana 
Hurtado-Villa, Paula 
Källén, Karin 
Landau, Danielle 
Lelong, Nathalie 
López Camelo, Jorge 
Martinez, Laura 
Morgan, Margery 
Mutchinick, Osvaldo M 
Pierini, Anna 
Rissmann, Anke 
Sipek, Antonin 
Szabova, Elena 
Wertelecki, Wladimir 
Zarante, Ignacio 
Bakker, Marian K 
Kancherla, Vijaya 
Mastroiacovo, Pierpaolo 
Nembhard, Wendy N 
Keywords: Mortalidad;Prevalencia
Issue Date: 2021
Journal: Annals of epidemiology 
This study determined the prevalence, mortality, and time trends of children with congenital diaphragmatic hernia (CDH).

Twenty-five hospital- and population-based surveillance programs in 19 International Clearinghouse for Birth Defects Surveillance and Research member countries provided birth defects mortality data between 1974 and 2015. CDH cases included live births, stillbirths, or elective termination of pregnancy for fetal anomalies. Prevalence, cumulative mortality rates, and 95% confidence intervals (CIs) were calculated using Poisson regression and a Kaplan–Meier product-limit method. Joinpoint regression analyses were conducted to assess time trends.

The prevalence of CDH was 2.6 per 10,000 total births (95% CI: 2.5–2.7), slightly increasing between 2001 and 2012 (average annual percent change = 0.5%; 95% CI:−0.6 to 1.6). The total percent mortality of CDH was 37.7%, with hospital-based registries having more deaths among live births than population-based registries (45.1% vs. 33.8%). Mortality rates decreased over time (average annual percent change = −2.4%; 95% CI: −3.8 to 1.1). Most deaths due to CDH occurred among 2- to 6-day-old infants for both registry types (36.3%, hospital-based; 12.1%, population-based).

The mortality of CDH has decreased over time. Mortality remains high during the first week and varied by registry type.
Fil: Politis, Maria D. Arkansas Center for Birth Defects Research and Prevention, and Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences; Estados Unidos

Fil: Bermejo-Sánchez, Eva. ECEMC (Spanish Collaborative Study of Congenital Malformations), CIAC (Research Center on Congenital Anomalies), Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III; España
DOI: 10.1016/j.annepidem.2020.11.007
Appears in Collections:Publicaciones INE

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