Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/241
Title: Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease
Authors: Sosa-Estani, Sergio 
Segura, Elsa L. 
Ruiz, Andrés Mariano 
Velazquez, Elsa 
Porcel, Betina Mabel 
Yampotis, Cristina 
Keywords: Enfermedad de Chagas;Nitroimidazoles;Tripanocidas;Método Doble Ciego;Niño
Issue Date: 1998
Description: A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi. Children were treated with benznidazole at a dose of 5 mg/kg/day for 60 days or placebo and followed-up for 48 months. The treated children showed a significant decrease in geometric mean titers of antibodies against T. cruzi measured by indirect hemagglutination, indirect immunofluorescence, and ELISA. After a four year follow-up, 62% of the benznidazole- treated children and no placebo-treated child were seronegative for T. cruzi when tested by an ELISA using a T. cruzi flagellar calcium-binding protein (F29). Xenodiagnosis carried out after 48 months of follow-up was positive in 4.7% of the benznidazole-treated children and in 51.2% of the placebo-treated children. These results show the tolerance to and efficacy of benznidazole against T. cruzi in seropositive children six to 12 years of age. We used an early serologic marker of cure after treatment, consisting of a recombinant antigen implemented in a rapid, conventional serologic procedure.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Segura, Elsa Leonor. ANLIS Dr.C.G.Malbrán; Argentina.
Fil: Ruiz, Andres Mariano. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Velazquez, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Porcel, Betina Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Yampotis, Cristina. Hospital San Roque; Argentina.
URI: http://www.ajtmh.org/content/59/4/526.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/241
ISSN: 1476-1645
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Publicaciones
Publicaciones CeNDIE
Publicaciones INP
snrd

Files in This Item:
File Description SizeFormat
TheAmericanJournalofTropicalMedicineandHygiene,1998,59(4),526–529..pdfPDF54.56 kBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

6
checked on Sep 19, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.