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Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/241
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dc.contributor.authorSosa-Estani, Sergio-
dc.contributor.authorSegura, Elsa L.-
dc.contributor.authorRuiz, Andrés Mariano-
dc.contributor.authorVelazquez, Elsa-
dc.contributor.authorPorcel, Betina Mabel-
dc.contributor.authorYampotis, Cristina-
dc.date.accessioned2012-10-20T21:14:23Z-
dc.date.available2012-10-20T21:14:23Z-
dc.date.issued1998-
dc.identifier.issn1476-1645-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/241-
dc.identifier.urihttp://www.ajtmh.org/content/59/4/526.full.pdf+html-
dc.descriptionA double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi. Children were treated with benznidazole at a dose of 5 mg/kg/day for 60 days or placebo and followed-up for 48 months. The treated children showed a significant decrease in geometric mean titers of antibodies against T. cruzi measured by indirect hemagglutination, indirect immunofluorescence, and ELISA. After a four year follow-up, 62% of the benznidazole- treated children and no placebo-treated child were seronegative for T. cruzi when tested by an ELISA using a T. cruzi flagellar calcium-binding protein (F29). Xenodiagnosis carried out after 48 months of follow-up was positive in 4.7% of the benznidazole-treated children and in 51.2% of the placebo-treated children. These results show the tolerance to and efficacy of benznidazole against T. cruzi in seropositive children six to 12 years of age. We used an early serologic marker of cure after treatment, consisting of a recombinant antigen implemented in a rapid, conventional serologic procedure.en_US
dc.descriptionFil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.en_US
dc.descriptionFil: Segura, Elsa Leonor. ANLIS Dr.C.G.Malbrán; Argentina.en_US
dc.descriptionFil: Ruiz, Andres Mariano. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.en_US
dc.descriptionFil: Velazquez, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.en_US
dc.descriptionFil: Porcel, Betina Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.en_US
dc.descriptionFil: Yampotis, Cristina. Hospital San Roque; Argentina.en_US
dc.formatapplication/pdfES
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.sourceThe American Journal of Tropical Medicine and Hygiene, 1998, 59(4), 526–529.en_US
dc.subjectEnfermedad de Chagasen_US
dc.subjectNitroimidazolesen_US
dc.subjectTripanocidasen_US
dc.subjectMétodo Doble Ciegoen_US
dc.subjectNiñoen_US
dc.titleEfficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' diseaseen_US
dc.typeArtículoes
anlis.essnrd1es
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeArtículo-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Parasitología (INP)-
crisitem.author.deptInstituto Nacional de Parasitología (INP)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Parasitología (INP)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
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