Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/2364
Title: Pharmaceutical biotechnological potential of filamentous fungi isolated from textile industry
Authors: Bernal, Suzan Prado Fernandes 
Gritti, Micaela Andrea 
Dos Santos, Viviane Piccin 
Ottoni, Júlia Ronzella 
de Oliveira, Valéria Maia 
Peichoto, María Elisa 
Passarini, Michel Rodrigo Zambrano 
Keywords: Colagenasa Microbiana;alfa 1-Antitripsina;Adyuvantes Farmacéuticos
Issue Date: 21-May-2021
Journal: Archives of microbiology 
Abstract: 
The need for more effective drugs for the treatment of infectious diseases as well as for general applications including wound healing and burn surgery, has guided efforts for the discovery of new compounds of medical interest. Microorganisms found in textile industrial waste have the ability to produce a variety of enzymes and/or secondary metabolites including molecules of pharmaceutical interest. The present work investigated the biotechnological potential of filamentous fungi isolated from textile industry wastewater for the production of collagenase and antimicrobial metabolites. From 28 isolates assayed, Sarocladium sp. ITF33 showed specific collagenolytic activity with values of 7.62 and 9.04 U mg-1 for the intracellular and extracellular fractions, respectively. The isolate Penicillium sp. ITF28 showed the best antimicrobial activity, reaching MIC ranging from 1.0 to 0.0625 mg mL-1 against five pathogenic bacteria. Molecular analyzes suggest that the isolate Sarocladium sp. ITF 33 can be considered a species not yet described. The results of the present work encourage studies of characterization and purification of the enzymes and secondary metabolites produced by the isolates found aiming future applications in the medical and pharmaceutical fields.
Description: 
Fil: Prado Fernandes Bernal, Suzan. Universidade Federal da Integração Latino-Americana. Laboratório de Biotecnologia Ambiental. Foz do Iguaçu; Brasil.

Fil: Gritti, Micaela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto Nacional de Medicina Tropical (INMeT) - ANLIS "Dr. Carlos G Malbrán". Misiones: Argentina.

Fil: Piccin Dos Santos, Viviane .CPQBA / UNICAMP - Divisão de Recursos Microbianos, Campinas; Brasil.

Fil: Ronzella Ottoni, Júlia. Universidade Federal da Integração Latino-Americana. Laboratório de Biotecnologia Ambiental. Foz do Iguaçu; Brasil.

Fil: Valéria Maia de Oliveira. CPQBA / UNICAMP - Divisão de Recursos Microbianos, Campinas; Brasil.

Fil: Peichoto, María Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto Nacional de Medicina Tropical (INMeT) - ANLIS "Dr. Carlos G Malbrán". Misiones: Argentina.

Fil: Zambrano Passarini, Michel Rodrigo. Universidade Federal da Integração Latino-Americana. Laboratório de Biotecnologia Ambiental. Foz do Iguaçu; Brasil.
URI: http://sgc.anlis.gob.ar/handle/123456789/2364
DOI: 10.1007/s00203-021-02379-3
Appears in Collections:Publicaciones INMeT

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