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Title: | Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole | Authors: | Fernández, Marisa Liliana Marson, Maria Elena Ramírez, Juan Carlos Mastrantonio, Guido Schijman, Alejandro Gabriel Altcheh, Jaime Riarte, Adelina Garcia-Bournissen, Facundo |
Keywords: | Farmacología;Enfermedad de Chagas;Acción Farmacodinámica del Medicamento Homeopático | Issue Date: | Mar-2016 | Journal: | Memorias do Instituto Oswaldo Cruz | Abstract: | Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults. We report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas disease treated with the new BNZ formulation (ABARAX®) in doses between 2.5-5.5 mg/Kg/day. All but one patient had plasmatic BNZ concentrations within the expected range. All patients finalised treatment with nondetectable Trypanosoma cruzi quantitative polymerase chain reaction, which remained nondetectable at the six month follow-up. Our data suggests parasitological responses with the new BNZ and supports the hypothesis that treatment protocols with lower BNZ doses may be effective. |
Description: | Fil: Fernández, Marisa Liliana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Marson, Maria Elena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Área de Toxicología; Argentina. Fil: Ramirez, Juan Carlos. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular. Laboratorio de Biología Molecular de la Enfermedad de Chagas, Buenos Aires; Argentina. Fil: Mastrantonio, Guido. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Área de Toxicología; Argentina. Fil: Schijman, Alejandro Gabriel. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular. Laboratorio de Biología Molecular de la Enfermedad de Chagas, Buenos Aires; Argentina. Fil: Altcheh, Jaime. Hospital de Niños Ricardo Gutiérrez. Servicio de Parasitología-Chagas, Buenos Aires; Argentina. Fil: Riarte, Adelina Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: García-Bournissen, Facundo. Hospital de Niños Ricardo Gutiérrez. Servicio de Parasitología-Chagas, Buenos Aires; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2162 | ISSN: | 1678-8060 | DOI: | 10.1590/0074-02760150401 | Rights: | Open Access Creative Commons Attribution 4.0 International License |
Appears in Collections: | Publicaciones INP |
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