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Title: | Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis | Authors: | Argüello, Rafael J Vigliano, Carlos Cabeza-Meckert, Patricia Viotti, Rodolfo Garelli, Fernando Favaloro, Liliana E Favaloro, Roberto R Laguens, Rubén Laucella, Susana A. |
Issue Date: | Aug-2014 | Journal: | PLoS neglected tropical diseases | Abstract: | The main consequence of chronic Trypanosoma cruzi infection is the development of myocarditis in approximately 20-30% of infected individuals but not until 10-20 years after the initial infection. We have previously shown that circulating interferon-γ-secreting T cells responsive to Trypanosoma cruzi antigens in chronic Chagas disease patients display a low grade of differentiation and the frequency of these T lymphocytes decreases along with the severity of heart disease. This study thought to explore the expression of inhibitory receptors, transcription factors of type 1 or regulatory T cells, and markers of T cell differentiation, immunosenescence or active cell cycle in cardiac explants from patients with advanced Chagas disease myocarditis. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1451 | DOI: | 10.1371/journal.pntd.0002989 |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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pntd.0002989.pdf | Artículo en inglés | 1.79 MB | Adobe PDF | View/Open |
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