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Title: Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis
Authors: Argüello, Rafael J 
Vigliano, Carlos 
Cabeza-Meckert, Patricia 
Viotti, Rodolfo 
Garelli, Fernando 
Favaloro, Liliana E 
Favaloro, Roberto R 
Laguens, Rubén 
Laucella, Susana A. 
Issue Date: Aug-2014
Journal: PLoS neglected tropical diseases 
The main consequence of chronic Trypanosoma cruzi infection is the development of myocarditis in approximately 20-30% of infected individuals but not until 10-20 years after the initial infection. We have previously shown that circulating interferon-γ-secreting T cells responsive to Trypanosoma cruzi antigens in chronic Chagas disease patients display a low grade of differentiation and the frequency of these T lymphocytes decreases along with the severity of heart disease. This study thought to explore the expression of inhibitory receptors, transcription factors of type 1 or regulatory T cells, and markers of T cell differentiation, immunosenescence or active cell cycle in cardiac explants from patients with advanced Chagas disease myocarditis.
DOI: 10.1371/journal.pntd.0002989
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