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http://sgc.anlis.gob.ar/handle/123456789/1432| Título: | Human Polymorphisms in Placentally Expressed Genes and Their Association With Susceptibility to Congenital Trypanosoma cruzi Infection | Autor(es): | Juiz, Natalia A. Cayo, Nelly M. Burgos, Marianela Salvo, Miriam E Nasser, Julio R. Bua, Jacqueline Longhi, Silvia A Schijman, Alejandro G. |
Palavras-chave: | Chagas congénita;Proteína ADAM12;ALPP;Metaloproteinasa 2 de la Matriz;Metaloproteinasa 9 de la Matriz;Polimorfismo de Nucleótido Simple | Data do documento: | 15-Abr-2016 | Jornal: | The Journal of infectious diseases | Resumo: | It is currently unclear why only a proportion of children born to Trypanosoma cruzi-infected mothers acquire the infection. We have examined the association of 11 single-nucleotide polymorphisms (SNPs) located in genes coding for placental expression enzymes as genetic markers of susceptibility to congenital T. cruzi infection (hereafter, "congenital infection"): rs2014683 and rs1048988 in ALPP; rs11244787 and rs1871054 in ADAM12; rs243866, rs243865, rs17859821, rs243864, and rs2285053 in MMP2; and rs3918242 and rs2234681 in MMP9. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1432 | DOI: | 10.1093/infdis/jiv561 |
| Aparece nas Coleções: | Publicaciones INP |
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