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Title: Human Polymorphisms in Placentally Expressed Genes and Their Association With Susceptibility to Congenital Trypanosoma cruzi Infection
Authors: Juiz, Natalia A. 
Cayo, Nelly M. 
Burgos, Marianela 
Salvo, Miriam E 
Nasser, Julio R. 
Bua, Jacqueline 
Longhi, Silvia A 
Schijman, Alejandro G. 
Keywords: Chagas congénita;Proteína ADAM12;ALPP;Metaloproteinasa 2 de la Matriz;Metaloproteinasa 9 de la Matriz;Polimorfismo de Nucleótido Simple
Issue Date: 15-Apr-2016
Journal: The Journal of infectious diseases 
Abstract: It is currently unclear why only a proportion of children born to Trypanosoma cruzi-infected mothers acquire the infection. We have examined the association of 11 single-nucleotide polymorphisms (SNPs) located in genes coding for placental expression enzymes as genetic markers of susceptibility to congenital T. cruzi infection (hereafter, "congenital infection"): rs2014683 and rs1048988 in ALPP; rs11244787 and rs1871054 in ADAM12; rs243866, rs243865, rs17859821, rs243864, and rs2285053 in MMP2; and rs3918242 and rs2234681 in MMP9.
DOI: 10.1093/infdis/jiv561
Appears in Collections:Publicaciones INP

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