Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1368
Title: Trypanosoma cruzi Infection at the Maternal-Fetal Interface: Implications of Parasite Load in the Congenital Transmission and Challenges in the Diagnosis of Infected Newborns
Authors: Bustos, Patricia L. 
Milduberger, Natalia 
Volta, Bibiana J. 
Perrone, Alina E. 
Laucella, Susana A. 
Bua, Jacqueline 
Keywords: Trypanosoma cruzi;Lactante;Diagnóstico Precoz;Mujeres Embarazadas;Transmisión Vertical de Enfermedad Infecciosa;Parasitemia
Issue Date: 7-Jun-2019
Publisher: Frontiers Media
Journal: Frontiers in microbiology 
Abstract: 
Trypanosoma cruzi is the protozoan unicellular parasite that causes Chagas disease. It can be transmitted from infected mothers to their babies via the connatal route, thus being able to perpetuate even in the absence of Triatomine insect vectors. Chagas disease was originally endemic in Central and South America, but migration of infected women of childbearing age has spread the T. cruzi congenital infection to non-endemic areas like North America, Europe, Japan, and Australia. Currently, 7 million people are affected by this infection worldwide. This review focuses on the relevance of the T. cruzi parasite levels in different aspects of the congenital T. cruzi infection such as the mother-to-child transmission rate, the maternal and fetal immune response, and its impact on the diagnosis of infected newborns. Improvements in detection of this parasite, with tools that can be easily adapted to be used in remote rural areas, will make the early diagnosis of infected children possible, allowing a prompt trypanocidal treatment and avoiding the current loss of opportunities for the diagnosis of 100% of T. cruzi congenitally infected infants.
Description: 
Fil: Bustos, Patricia L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Milduberger, Natalia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Volta, Bibiana J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Perrone, Alina E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Bua, Jacqueline. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/1368
https://doi.org/10.3389/fmicb.2019.01250
ISSN: 1664-302X
DOI: 10.3389/fmicb.2019.01250
Rights: Open Access
Creative Commons Attribution 4.0 International License
Appears in Collections:Publicaciones INP

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