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Title: Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease
Authors: Pengue, Claudia 
Cesar, Gonzalo 
Alvarez, María Gabriela 
Bertocchi, Graciela 
Lococo, Bruno 
Viotti, Rodolfo 
Natale, María Ailén 
Castro Eiro, Melisa D 
Cambiazzo, Silvia S 
Perroni, Nancy 
Nuñez, Myriam 
Albareda, María Cecilia 
Laucella, Susana A. 
Issue Date: 2019
Journal: PloS one 
Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased sera levels of soluble P-selectin are associated with the severity of the cardiomyopathy distinctive of chronic Chagas disease. In this study, we explored the expression of biomarkers of platelet and endothelial activation, tissue remodeling, and mediators of the coagulation cascade in patients at different clinical stages of chronic Chagas heart disease. The frequencies of activated platelets, measured by the expression of CD41a and CD62P were decreased in patients with chronic Chagas disease compared with those in uninfected subjects, with an inverse association with disease severity. Platelet activation in response to adenosine diphosphate was also decreased in T. cruzi-infected subjects. A major proportion of T. cruzi infected subjects showed increased serum levels of fibrinogen. Patients with severe cardiac dysfunction showed increased levels of endothelin-1 and normal values of procollagen I. In conclusion, chronic infection with T. cruzi induced hemostatic alterations, even in those patients who do not yet present cardiac symptoms.
DOI: 10.1371/journal.pone.0218260
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