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|Title:||Redirection of the Immune Response to the Functional Catalytic Domain of the Cystein Proteinase Cruzipain Improves Protective Immunity against Trypanosoma cruzi Infection||Authors:||Cazorla, Silvia I.
Frank, Fernanda M.
Becker, Pablo D.
Arnaiz, María Rosa
Mirkin, Gerardo A.
Corral, Ricardo S.
Guzman, Carlos A.
Malchiodi, Emilio L.
|Issue Date:||2010||Description:||Despite the strong immune responses elicited after natural infection with Trypanosoma cruzi or vaccination against it, parasite survival suggests that these responses are insufficient or inherently inadequate. T. cruzi contains a major cystein proteinase, cruzipain, which has a catalytic N-terminal domain and a C-terminal extension. Immunizations that employed recombinant cruzipain or its N- and C-terminal domains allowed evaluation of the ability of cruzipain to circumvent responses against the catalytic domain. This phenomenon is not a property of the parasite but of cruzipain itself, because recombinant cruzipain triggers a response similar to that of cruzipain during natural or experimental infection. Cruzipain is not the only antigen with a highly immunogenic region of unknown function that somehow protects an essential domain for parasite survival. However, our studies show that this can be reverted by using the N- terminal domain as a tailored immunogen able to redirect host responses to provide enhanced protection.||URI:||http://sgc.anlis.gob.ar/handle/123456789/533||Rights:||info:eu-repo/semantics/openAccess|
|Appears in Collections:||Publicaciones INP|
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|JournalofInfectiousDiseases,2010,202(1),136-144..pdf||5.09 MB||Adobe PDF|
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