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Title: | Assessment of CD8(+) T cell differentiation in Trypanosoma cruzi-infected children | Authors: | Albareda, María Cecilia Olivera, Gabriela C De Rissio, Ana María Postan, Miriam |
Keywords: | Enfermedad de Chagas;Linfocitos T CD8-positivos;Diferenciación Celular;Citocinas;Regulación de la Expresión Génica | Issue Date: | 2010 | Journal: | The American journal of tropical medicine and hygiene | Abstract: | We previously reported that the T cell compartment in chronically Trypanosoma cruzi-infected adult subjects display functional and phenotypic signs of immune senescence. This study aimed to investigate the differentiation and the senescent profile of the overall CD8(+) T cell compartment in T. cruzi-infected children at the early stage of the disease. We found a lower percentage of naive (CD27(+)CD28(+)CD45RA(+)) and early antigen-experienced (CD45RA(-)CD27(+)CD28(+)), and higher percentages of late differentiated antigen-experienced (CD45RA(-)CD27(-)CD28(-)) CD8(+) T cells in T. cruzi-infected children as compared with age-matched uninfected controls. The expression of the interleukin (IL)-7R is also decreased on naive and on antigen-experienced total CD8(+) T cells with various degrees of differentiation. Conversely, the expression of HLA-DR, caspase-3, and CD57 did not vary on the total CD8(+) T cell compartment. These findings suggest that the duration of the infection is relevant in the process of immune senescent that this parasite can induce. |
Description: | Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Olivera, Gabriela C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/531 | ISSN: | 1476-1645 | DOI: | https://doi.org/10.4269/ajtmh.2010.09-0604 | Rights: | info:eu-repo/semantics/openAccess Open Access Creative Commons Attribution 4.0 International License |
Appears in Collections: | Preproducción Publicaciones INP |
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AMJTMH_2010_82_5_861-864.pdf | Artículo en inglés | 659.94 kB | Adobe PDF | View/Open |
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