Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/531
Title: Assessment of CD8(+) T cell differentiation in Trypanosoma cruzi-infected children
Authors: Albareda, María Cecilia 
Olivera, Gabriela C 
De Rissio, Ana María 
Postan, Miriam 
Keywords: Enfermedad de Chagas;Linfocitos T CD8-positivos;Diferenciación Celular;Citocinas;Regulación de la Expresión Génica
Issue Date: 2010
Journal: The American journal of tropical medicine and hygiene 
Abstract: 
We previously reported that the T cell compartment in chronically Trypanosoma cruzi-infected adult subjects display functional and phenotypic signs of immune senescence. This study aimed to investigate the differentiation and the senescent profile of the overall CD8(+) T cell compartment in T. cruzi-infected children at the early stage of the disease. We found a lower percentage of naive (CD27(+)CD28(+)CD45RA(+)) and early antigen-experienced (CD45RA(-)CD27(+)CD28(+)), and higher percentages of late differentiated antigen-experienced (CD45RA(-)CD27(-)CD28(-)) CD8(+) T cells in T. cruzi-infected children as compared with age-matched uninfected controls. The expression of the interleukin (IL)-7R is also decreased on naive and on antigen-experienced total CD8(+) T cells with various degrees of differentiation. Conversely, the expression of HLA-DR, caspase-3, and CD57 did not vary on the total CD8(+) T cell compartment. These findings suggest that the duration of the infection is relevant in the process of immune senescent that this parasite can induce.
Description: 
Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Olivera, Gabriela C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/531
ISSN: 1476-1645
DOI: https://doi.org/10.4269/ajtmh.2010.09-0604
Rights: info:eu-repo/semantics/openAccess
Open Access
Creative Commons Attribution 4.0 International License
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Publicaciones INP

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