Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/451
Title: Effect of Shiga toxin 2 on water and ion transport in human colon in vitro
Authors: Fiorito, Paula 
Burgos, Juan M. 
Miyakawa, Mariano Fernandez 
Rivas, Marta 
Chillemi, Germán 
Berkowski, Dario 
Zotta, Elsa 
Silberstein, Claudia 
Ibarra, Cristina 
Issue Date: 2000
Description: Shiga toxin-producing Escherichia coli (STEC) colonize the lower segments of the human gastrointestinal tract, causing gastrointestinal and systemic diseases. In this study, the effects of Shiga toxin 2 (Stx2) on fluid absorption and ion transport in the human colon were examined. Net water movement (Jw) and short-circuit current (Isc) were simultaneously measured across the colonic mucosa incubated with crude or purified Stx2. Stx2 significantly inhibited the absorptive J(w) with no effect on the basal I-sc after 60 min of exposure. These effects may be due to the inhibition of a nonelectrogenic transport system present in the surface colonic villus cells. Morphological studies of the colonic mucosa treated with crude or purified Stx2 demonstrated a selective damage in the absorptive villus epithelial cells. These findings suggest that Stx2, inhibits water absorption across the human colon by acting on a specific cell population: the mature, differentiated absorptive villus epithelium.
URI: http://sgc.anlis.gob.ar/handle/123456789/451
Rights: restrictedAccess
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