Please use this identifier to cite or link to this item:
Title: Effect of Shiga toxin 2 on water and ion transport in human colon in vitro
Authors: Fiorito, Paula 
Burgos, Juan M. 
Miyakawa, Mariano Fernandez 
Rivas, Marta 
Chillemi, Germán 
Berkowski, Dario 
Zotta, Elsa 
Silberstein, Claudia 
Ibarra, Cristina 
Issue Date: 2000
Description: Shiga toxin-producing Escherichia coli (STEC) colonize the lower segments of the human gastrointestinal tract, causing gastrointestinal and systemic diseases. In this study, the effects of Shiga toxin 2 (Stx2) on fluid absorption and ion transport in the human colon were examined. Net water movement (Jw) and short-circuit current (Isc) were simultaneously measured across the colonic mucosa incubated with crude or purified Stx2. Stx2 significantly inhibited the absorptive J(w) with no effect on the basal I-sc after 60 min of exposure. These effects may be due to the inhibition of a nonelectrogenic transport system present in the surface colonic villus cells. Morphological studies of the colonic mucosa treated with crude or purified Stx2 demonstrated a selective damage in the absorptive villus epithelial cells. These findings suggest that Stx2, inhibits water absorption across the human colon by acting on a specific cell population: the mature, differentiated absorptive villus epithelium.
Rights: restrictedAccess
Appears in Collections:Publicaciones INEI

Files in This Item:
File Description SizeFormat
DigestiveDiseasesandSciences,45(3),480-486..pdfPDF1.28 MBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Sep 21, 2019


checked on Sep 21, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.