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Title: | Effect of Shiga toxin 2 on water and ion transport in human colon in vitro | Authors: | Fiorito, Paula Burgos, Juan M. Fernández-Miyakawa, Mariano E Rivas, Marta Chillemi, Germán Berkowski, Dario Zotta, Elsa Silberstein, Claudia Ibarra, Cristina |
Issue Date: | 2000 | Description: | Shiga toxin-producing Escherichia coli (STEC) colonize the lower segments of the human gastrointestinal tract, causing gastrointestinal and systemic diseases. In this study, the effects of Shiga toxin 2 (Stx2) on fluid absorption and ion transport in the human colon were examined. Net water movement (Jw) and short-circuit current (Isc) were simultaneously measured across the colonic mucosa incubated with crude or purified Stx2. Stx2 significantly inhibited the absorptive J(w) with no effect on the basal I-sc after 60 min of exposure. These effects may be due to the inhibition of a nonelectrogenic transport system present in the surface colonic villus cells. Morphological studies of the colonic mucosa treated with crude or purified Stx2 demonstrated a selective damage in the absorptive villus epithelial cells. These findings suggest that Stx2, inhibits water absorption across the human colon by acting on a specific cell population: the mature, differentiated absorptive villus epithelium. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/451 | Rights: | restrictedAccess |
Appears in Collections: | Preproducción Publicaciones INEI |
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File | Description | Size | Format | |
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DigestiveDiseasesandSciences,45(3),480-486..pdf | 1.28 MB | Adobe PDF | View/Open |
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