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Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/451
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dc.contributor.authorFiorito, Paulaes
dc.contributor.authorBurgos, Juan M.es
dc.contributor.authorFernández-Miyakawa, Mariano Ees
dc.contributor.authorRivas, Martaes
dc.contributor.authorChillemi, Germánes
dc.contributor.authorBerkowski, Darioes
dc.contributor.authorZotta, Elsaes
dc.contributor.authorSilberstein, Claudiaes
dc.contributor.authorIbarra, Cristinaes
dc.date.accessioned2013-03-29T22:59:53Z
dc.date.available2013-03-29T22:59:53Z
dc.date.issued2000-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/451-
dc.descriptionShiga toxin-producing Escherichia coli (STEC) colonize the lower segments of the human gastrointestinal tract, causing gastrointestinal and systemic diseases. In this study, the effects of Shiga toxin 2 (Stx2) on fluid absorption and ion transport in the human colon were examined. Net water movement (Jw) and short-circuit current (Isc) were simultaneously measured across the colonic mucosa incubated with crude or purified Stx2. Stx2 significantly inhibited the absorptive J(w) with no effect on the basal I-sc after 60 min of exposure. These effects may be due to the inhibition of a nonelectrogenic transport system present in the surface colonic villus cells. Morphological studies of the colonic mucosa treated with crude or purified Stx2 demonstrated a selective damage in the absorptive villus epithelial cells. These findings suggest that Stx2, inhibits water absorption across the human colon by acting on a specific cell population: the mature, differentiated absorptive villus epithelium.en_US
dc.rightsrestrictedAccessen_US
dc.sourceDigestive Diseases and Sciences, 45(3), 480-486.en_US
dc.titleEffect of Shiga toxin 2 on water and ion transport in human colon in vitroes
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptDepartamento de Bacteriología-
crisitem.author.deptServicio de Fisiopatogenia-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgDepartamento de Bacteriología-
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