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Title: | Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina | Authors: | Garcia, Javier F Nastro, Marcela Dabos, Laura Campos, Josefina Traglia, German M Ocampo, Cecilia Vera Famiglietti, Angela Rodriguez, Carlos H Vay, Carlos A |
Keywords: | carbapenemasas;resistencia a la colistina;Resistencia a Múltiples Medicamentos;infecciones nosocomiales | Issue Date: | May-2022 | Journal: | Microbial drug resistance (Larchmont, N.Y.) | Abstract: | The spread of carbapenem-resistant Enterobacterales has raised concern in clinical settings due to the limited therapeutic options available. OXA-48-like enzymes are still sporadic in South America. The aim of this study was to characterize a multidrug-resistant Escherichia coli isolate from a hospitalized patient in Buenos Aires city. The isolate was characterized phenotypically by determination of its susceptibility pattern, synergistic and colorimetric tests, and molecularly, by PCR, whole genome sequencing, and plasmid analysis. It belonged to ST-744, phylogroup A, and serotype O162/O89: H9. It remained susceptible to ceftazidime, meropenem, aminoglycosides, trimethoprim/sulfamethoxazole, and tigecycline. The presence of blaOXA-232 harbored by a nonconjugative plasmid ColKp3, and blaCTX-M-14, mcr-1.1, and fosL1 in 2 conjugative plasmids, together with their genetic environment, was revealed. To the best of our knowledge, this is the first report of the coproduction of the enzyme OXA-232 and the mcr-1.1 gene in an E. coli clinical isolate in South America in a patient who had not received colistin therapy. |
Description: | Fil: Garcia, Javier F. Cátedra de Microbiología Clínica, Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires; Buenos Aires, Argentina Fil: Nastro, Marcela. Cátedra de Microbiología Clínica, Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, INFIBIOC, Universidad de Buenos Aires; Buenos Aires, Argentina Fil: Dabos, Laura. Evolutionary Systems Genetics of Microbes Laboratory, Center for Plant Biotechnology and Genomics (CBGP, UPM-INIA) Technical University of Madrid; Madrid, España Fil: Campos, Josefina. Plataforma Genómica y Bioinformática ANLIS "Dr Carlos G Malbran"; Buenos Aires, Argentina Fil: Traglia, German. Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República; Montevideo, Uruguay Fil: Vera Ocampo, Cecilia. Servicio de Infectología, Sanatorio Mater Dei, Ciudad Autónoma de Buenos Aires; Buenos Aires, Argentina Fil: Famiglietti, Angela. Cátedra de Microbiología Clínica, Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, INFIBIOC, Universidad de Buenos Aires; Buenos Aires, Argentina Fil: Rodriguez, Carlos H. Cátedra de Microbiología Clínica, Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, INFIBIOC, Universidad de Buenos Aires; Buenos Aires, Argentina Fil: Vay, Carlos A. Laboratorio de Bacteriología. Sanatorio Mater Dei, Ciudad Autónoma de Buenos Aires; Buenos Aires, Argentina |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2516 | DOI: | 10.1089/mdr.2021.0167 |
Appears in Collections: | Artículos |
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