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Title: | The Importance of Shiga Toxin-Producing Escherichia coli O145:NM[H28]/H28 Infections in Argentina, 1998-2020 | Authors: | Carbonari, Claudia Carolina Miliwebsky, Elizabeth Sandra Zolezzi, Gisela Deza, Natalia Lorena Fittipaldi, Nahuel Manfredi, Eduardo Baschkier, Ariela D'Astek, Beatriz Alejandra Melano, Roberto Gustavo Schesi, Carla Rivas, Marta Chinen, Isabel |
Keywords: | STEC O145;Epidemiología;Variación Genética;Síndrome Hemolítico-Urémico;Vigilancia | Issue Date: | 7-Mar-2022 | Journal: | Microorganisms | Abstract: | Shiga toxin-producing Escherichia coli (STEC) is known as a pathogen associated with food-borne diseases. The STEC O145 serogroup has been related with acute watery diarrhea, bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Argentina has the highest rate of HUS worldwide with 70% of the cases associated with STEC infections. We aimed to describe the epidemiology and genetic diversity of STEC O145 strains isolated across Argentina between 1998-2020. The strains isolated from 543 cases of human disease and four cattle, were pheno-genotipically characterized. Sequencing of five strains was performed. The strains were serotyped as O145:NM[H28]/H28, O145:H25, and O145:HNT, and mainly characterized as O145:NM[H28]/stx2a/eae/ehxA (98.1%). The results obtained by sequencing were consistent with those obtained by traditional methods and additional genes involved in different mechanisms of the pathogen were observed. In this study, we confirmed that STEC O145 strains are the second serogroup after O157 and represent 20.3% of HUS cases in Argentina. The frequency of STEC O145 and other significant serogroups is of utmost importance for public health in the country. This study encourages the improvement of the surveillance system to prevent severe cases of human disease. |
Description: | Fil: Carbonari, Claudia Carolina. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Miliwebsky, Elizabeth Sandra. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Zolezzi, Gisela. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Deza, Natalia Lorena. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Fittipaldi, Nahuel. Faculty of Veterinary Medicine, University of Montreal; Canada Fil: Manfredi, Eduardo. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Baschkier, Ariela. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: D'Astek, Beatriz Alejandra. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Melano, Roberto Gustavo. Public Health Ontario, Toronto Laboratories; Canada Fil: Schesi, Carla. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Rivas, Marta. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina Fil: Chinen, Isabel. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2498 | ISSN: | 2076-2607 | DOI: | 10.3390/microorganisms10030582 |
Appears in Collections: | Artículos |
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microorganisms-10-00582.pdf | 9.54 MB | Adobe PDF | View/Open |
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