Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/2498
Title: The Importance of Shiga Toxin-Producing Escherichia coli O145:NM[H28]/H28 Infections in Argentina, 1998-2020
Authors: Carbonari, Claudia Carolina 
Miliwebsky, Elizabeth Sandra 
Zolezzi, Gisela 
Deza, Natalia Lorena 
Fittipaldi, Nahuel 
Manfredi, Eduardo 
Baschkier, Ariela 
D'Astek, Beatriz Alejandra 
Melano, Roberto Gustavo 
Schesi, Carla 
Rivas, Marta 
Chinen, Isabel 
Keywords: STEC O145;Epidemiología;Variación Genética;Síndrome Hemolítico-Urémico;Vigilancia
Issue Date: 7-Mar-2022
Journal: Microorganisms 
Abstract: 
Shiga toxin-producing Escherichia coli (STEC) is known as a pathogen associated with food-borne diseases. The STEC O145 serogroup has been related with acute watery diarrhea, bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Argentina has the highest rate of HUS worldwide with 70% of the cases associated with STEC infections. We aimed to describe the epidemiology and genetic diversity of STEC O145 strains isolated across Argentina between 1998-2020. The strains isolated from 543 cases of human disease and four cattle, were pheno-genotipically characterized. Sequencing of five strains was performed. The strains were serotyped as O145:NM[H28]/H28, O145:H25, and O145:HNT, and mainly characterized as O145:NM[H28]/stx2a/eae/ehxA (98.1%). The results obtained by sequencing were consistent with those obtained by traditional methods and additional genes involved in different mechanisms of the pathogen were observed. In this study, we confirmed that STEC O145 strains are the second serogroup after O157 and represent 20.3% of HUS cases in Argentina. The frequency of STEC O145 and other significant serogroups is of utmost importance for public health in the country. This study encourages the improvement of the surveillance system to prevent severe cases of human disease.
Description: 
Fil: Carbonari, Claudia Carolina. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Miliwebsky, Elizabeth Sandra. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Zolezzi, Gisela. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Deza, Natalia Lorena. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Fittipaldi, Nahuel. Faculty of Veterinary Medicine, University of Montreal; Canada

Fil: Manfredi, Eduardo. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Baschkier, Ariela. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: D'Astek, Beatriz Alejandra. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Melano, Roberto Gustavo. Public Health Ontario, Toronto Laboratories; Canada

Fil: Schesi, Carla. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Rivas, Marta. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina

Fil: Chinen, Isabel. Servicio Fisiopatogenia, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Buenos Aires 1282, Argentina
URI: http://sgc.anlis.gob.ar/handle/123456789/2498
ISSN: 2076-2607
DOI: 10.3390/microorganisms10030582
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