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Título: | Pseudomonas putida group species as reservoirs of mobilizable Tn402-like class 1 integrons carrying blaVIM-2 metallo-β-lactamase genes | Autor(es): | Brovedan, Marco A Marchiaro, Patricia M Rodríguez Díaz, María Elena Faccone, Diego Corso, Alejandra Pasteran, Fernando Viale, Alejandro M. Limansky, Adriana S. |
Palavras-chave: | Carbapenem resistance plasmids;Secuencias Repetitivas Esparcidas;Pseudomonas putida group;Tn21;Tn402-like class 1 integrons;VIM-2 metallo-β-lactamase reservoirs | Data do documento: | Dez-2021 | Jornal: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases | Resumo: | The Pseudomonas putida group (P. putida G) is composed of at least 21 species associated with a wide range of environments, including the clinical setting. Here, we characterized 13 carbapenem-resistant P. putida G clinical isolates bearing class 1 integrons/transposons (class 1 In/Tn) carrying blaVIM-2 metallo-β-lactamase gene cassettes obtained from hospitals of Argentina. Multilocus sequencing (MLSA) and phylogenetic analyses based on 16S rDNA, gyrB and rpoD sequences distinguished 7 species among them. blaVIM-2 was found in three different cassette arrays: In41 (blaVIM-2-aacA4), In899 (only blaVIM-2), and In528 (dfrB1-aacA4-blaVIM-2). In41 and In899 were associated with complete tniABQC transposition modules and IRi/IRt boundaries characteristic of the Tn5053/Tn402 transposons, which were designated Tn6335 and Tn6336, respectively. The class 1 In/Tn element carrying In528, however, exhibited a defective tni module bearing only the tniC (transposase) gene, associated with a complete IS6100 bounded with two oppositely-oriented IRt end regions. In some P. putida G isolates including P. asiatica, P. juntendi, P. putida G/II, and P. putida G/V, Tn6335/Tn6336 were carried by pLD209-type conjugative plasmids capable of self-mobilization to P. aeruginosa or Escherichia coli. In other isolates of P. asiatica, P. putida G/II, and P. monteiliieilii, however, these blaVIM-2-containing class 1 In/Tn elements were found inserted into the res regions preceding the tnpR (resolvase) gene of particular Tn21 subgroup members of Tn3 transposons. The overall results reinforce the notion of P. putida G members as blaVIM-2 reservoirs, and shed light on the mechanisms of dissemination of carbapenem resistance genes to other pathogenic bacteria in the clinical setting. |
Descrição: | Fil: Brovedan, Marco A. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Rosario, Argentina Fil: Marchiaro, Patricia M. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Rosario, Argentina Fil: Díaz, María S. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Rosario, Argentina Fil: Faccone, Diego. Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires, Argentina Fil: Corso, Alejandra. Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires, Argentina Fil: Pasteran, Fernando. Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires, Argentina Fil: Viale, Alejandro M. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Rosario, Argentina Fil: Limansky, Adriana S. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Rosario, Argentina |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2494 | DOI: | 10.1016/j.meegid.2021.105131 |
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1-s2.0-S1567134821004317-main.pdf | 2.63 MB | Adobe PDF | Ver/Aberto |
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