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http://sgc.anlis.gob.ar/handle/123456789/2492| Title: | Delayed viral clearance despite high number of activated T cells during the acute phase in Argentinean patients with hantavirus pulmonary syndrome | Authors: | Iglesias, Ayelén Aluminé Periolo, Natalia Bellomo, Carla María Lewis, Lorena Cecilia Olivera, Camila Paula Anselmo, Constanza Rosario García, Marina Coelho, Rocío María Alonso, Daniel Oscar Dighero-Kemp, Bonnie Sharma, Heema Kuhn, Jens H Di Paola, Nicholas Sanchez-Lockhart, Mariano Palacios, Gustavo Schierloh, Luis Pablo Martínez, Valeria Paula |
Keywords: | Hantavirus;Hantaviridae;Síndrome Pulmonar por Hantavirus;orthohantavirus | Issue Date: | Jan-2022 | Journal: | EBioMedicine | Abstract: | The hallmarks of HPS are increase of vascular permeability and endothelial dysfunction. Although an exacerbated immune response is thought to be implicated in pathogenesis, clear evidence is still elusive. As orthohantaviruses are not cytopathic CD8+ T cells are believed to be the central players involved in pathogenesis. |
Description: | Fil: Iglesias, Ayelén Aluminé. Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán; Buenos Aires, Argentina Fil: Períolo, Natalia. Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán; Buenos Aires, Argentina Fil: Bellomo, María Carla. Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán; Buenos Aires, Argentina Fil: Lewis, Lorena Cecilia. Hospital Zonal de Esquel, Ministerio de Salud de Chubut; Esquel, Argentina Fil: Olivera, Camila Paula. Hospital Zonal de Esquel, Ministerio de Salud de Chubut; Esquel, Argentina Fil: Anselmo, Constanza Rosario. Hospital Zonal de Esquel, Ministerio de Salud de Chubut; Esquel, Argentina Fil: García, Marina. Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital; Sweden Fil: Coelho, Rocío María. Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán; Buenos Aires, Argentina Fil: Alonso, Daniel Oscar. Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán; Buenos Aires, Argentina Fil: Dighero-Kemp, Bonnie. Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; United States Fil: Sharma, Heema. Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; United States Fil: Kuhn, Jens H. Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; United States Fil: Di Paola, Nicholas. Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases; United States Fil: Sanchez-Lockhart, Mariano. Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases; United States Fil: Palacios, Gustavo. Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases; United States Fil: Schierloh, Luis Pablo. Instituto de Investigación y Desarrollo en Bioingenieria y Bioinformatica, Universidad Nacional de Entre Ríos, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Buenos Aires, Argentina Fil: Martínez, Valeria Paula. Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán; Buenos Aires, Argentina |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2492 | DOI: | 10.1016/j.ebiom.2021.103765 |
| Appears in Collections: | Artículos |
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