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http://sgc.anlis.gob.ar/handle/123456789/242| Title: | Hantavirus pulmonary syndrome in northwestern Argentina : circulation of Laguna Negra virus associated with Calomys callosus | Authors: | Levis, Silvana Garcia, Jorge Pini, Noemí Calderón, Gladys Ramírez, Josefina Bravo, Daniel St. Jeor, Stephen Ripoll, Carlos Bego, Mariana Lozano, Elena Barquez, Rubén Ksiazek, Thomas G. Enria, Delia |
Keywords: | Hantavirus;Síndrome Pulmonar por Hantavirus;Filogenia;Ratas;Reacción en Cadena de la Polimerasa de Transcriptasa Inversa;ARN Viral;Roedores;Humanos;Argentina | Issue Date: | 2004 | Description: | The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses. Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina. Fil: Garcia, Jorge. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina. Fil: Pini, Noemí. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina. Fil: Calderón, Gladys. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina. Fil: Ramírez, Josefina. Hospital San Miguel; Argentina. Fil: Bravo, Daniel. Hospital Oscar Orías; Argentina. Fil: St. Jeor, Stephen. University of Nevada. Department of Microbiology; Estados Unidos. Fil: Ripoll, Carlos. Dirección de Epidemiología. San Salvador de Jujuy, Jujuy; Argentina. Fil: Bego, Mariana. University of Nevada. Department of Microbiology; Estados Unidos. Fil: Lozano, Elena. Hospital San Miguel; Argentina. Fil: Barquez, Rubén. Fundación Miguel Lillo; Argentina. Fil: Ksiazek, Thomas G. Centers for Disease Control and Prevention. Special Pathogens Branch; Estados Unidos. Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina. |
URI: | http://www.ajtmh.org/content/71/5/658.full.pdf+html http://sgc.anlis.gob.ar/handle/123456789/242 |
ISSN: | 1476-1645 | Rights: | info:eu-repo/semantics/openAccess |
| Appears in Collections: | snrd Publicaciones INEVH |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| TheAmericanJournalofTropicalMedicineandHygiene,2004,71(5),658–663..pdf | 114.17 kB | Adobe PDF |  View/Open |
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