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http://sgc.anlis.gob.ar/handle/123456789/238| Title: | Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina | Authors: | Mallimaci, María Cristina Sosa-Estani, Sergio Russomando, Graciela Sanchez Leon, Zunilda Sijvarger, Carina Alvarez, Isabel Marcela Barrionuevo, Lola Lopez, Carlos Segura, Elsa L. |
Keywords: | Trypanosoma cruzi;Enfermedad de Chagas;Recién Nacido;Complicaciones Parasitarias del Embarazo;Argentina | Issue Date: | 2010 | Description: | Chagas’ disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi . It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure. Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia. Laboratorio Central; Argentina. Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina. Fil: Russomando, Graciela. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay. Fil: Sanchez, Zunilda. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay. Fil: Sijvarger, Carina. Hospital Regional Ushuaia. Laboratorio Central; Argentina. Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia. Laboratorio Central; Argentina. Fil: Barrionuevo, Lola. Hospital Regional Ushuaia. Laboratorio Central; Argentina. Fil: Lopez, Carlos. Hospital Regional Ushuaia. Laboratorio Central; Argentina. Fil: Segura, Elsa, Leonor. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina. |
URI: | http://www.ajtmh.org/content/82/1/55.full.pdf+html http://sgc.anlis.gob.ar/handle/123456789/238 |
ISSN: | 1476-1645 | Rights: | info:eu-repo/semantics/openAccess |
| Appears in Collections: | snrd Publicaciones CeNDIE Publicaciones INP |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| TheAmericanJournalofTropicalMedicineandHygiene,2010,82(1),55–59..pdf | 554.42 kB | Adobe PDF |  View/Open |
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