Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/234
Title: Características biológicas e inmunológicas del veneno de Bothrops cotiara(Serpentes : Viperidae)
Other Titles: Biological and immunological characteristics of the poison of Bothrops cotiara (Serpentes : Viperidae)
Authors: de Roodt, Adolfo R. 
Estévez, Judith 
Dolab, Jorge A. 
Manzanelli, Marcelo Víctor 
Piñeiro, Nicolás 
Paniagua, Jorge Francisco 
Urs Vogt, Alejandro 
Keywords: Serpientes;Toxicidad;Neutralización;Viperidae
Issue Date: 2006
Description: Bothrops cotiarais a venomous snake sporadically found in the province of Misiones in Argentina, South of Brazil and Paraguay. Data on the clinics of the envenomation produced by its bite and on its venom are scarce. There is no information on the neutralizing capacity of the antivenoms available. In this study, the lethal potency, hemorrhagic, necrotizing, coagulant and thrombin-like, defibrinogenating, indirect hemolytic and fibrinolytic activities of the venom of B. cotiaraspecimens from the province of Misiones were determined. The toxic activities were within the range of those described for the other Bothropsspecies from Argentina, and the electrophoretic and chromatographic studies showed similarities with those described for the other bothropic venoms. The immunochemical reactivity of six South American anti Viper antivenoms (ELISA) have a strong reactivity with all the antivenoms studied. The neutralizing capacity of three of these therapeutic antivenoms against the lethal potency and hemorrhagic, necrotizing, coagulant, thrombin-like and hemolytic activities showed a very close neutralizing capacity. Our data strongly suggest that the antivenoms for therapeutic use available in this area of South America are useful to neutralize the toxic and enzymatic activities of the venom of this uncommon specie of Bothrops.
Fil: de Roodt, Adolfo R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Estévez, Judith. Instituto Bioclón S.A. de C.V.; México.
Fil: Dolab, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Manzanelli, Marcelo Víctor. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Piñeiro, Nicolás. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Paniagua, Jorge Francisco. Laboratorios Silanes S.A. de C.V.: México.
Fil: Urs Vogt, Alejandro. Centro Zootoxicológico de Misiones; Argentina.
URI: http://www.scielo.sa.cr/pdf/rbt/v54n3/3877.pdf
http://sgc.anlis.gob.ar/handle/123456789/234
ISSN: 0034-7744
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Publicaciones INPB
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