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Title: | Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group | Authors: | Maiztegui, Julio I. McKee Jr, Kelly T. Barrera Oro, Julio G. Harrison, Lee H Gibbs, P H Feuillade, María Rosa Enria, Delia Briggiler, Ana M. Levis, Silvana Ambrosio, Ana María Halsey, Neal A. Peters, Clarence J. |
Keywords: | Fiebre Hemorrágica Americana;Arenavirus;Virus Junin | Issue Date: | Feb-1998 | Publisher: | Oxford University Press | Journal: | The Journal of infectious diseases | Abstract: | Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious. |
Description: | Fil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: McKee Jr, K. T. Womack Army Medical Center, Fort Bragg, North Carolina; Estados Unidos. Fil: Barrera Oro, J G. ANLIS Dr.C.G.Malbrán; Argentina. Fil: Harrison, L H. University of Pittsburgh Graduate School of Public Health,Pittsburgh, Pennsylvania; Estados Unidos. Fil: Gibbs, P H. Division of Disease Assessment, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701; Estados Unidos. Fil: Feuillade, María Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Briggiler, Ana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Halsey, N A. Department of International Health, Johns Hopkins Medical Institutions, Baltimore, Maryland; Estados Unidos. Fil: Peters, C J. Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia; Estados Unidos. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2221 | ISSN: | 0022-1899 | DOI: | 10.1086/514211 | Rights: | Open Access |
Appears in Collections: | Publicaciones INEVH |
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File | Description | Size | Format | |
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10.1086_514211..pdf | Artículo en inglés | 147.13 kB | Adobe PDF | View/Open |
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