Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/2221
Title: Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
Authors: Maiztegui, Julio I. 
McKee Jr, Kelly T. 
Barrera Oro, Julio G. 
Harrison, Lee H 
Gibbs, P H 
Feuillade, María Rosa 
Enria, Delia 
Briggiler, Ana M. 
Levis, Silvana 
Ambrosio, Ana María 
Halsey, Neal A. 
Peters, Clarence J. 
Keywords: Fiebre Hemorrágica Americana;Arenavirus;Virus Junin
Issue Date: Feb-1998
Publisher: Oxford University Press
Journal: The Journal of infectious diseases 
Abstract: 
Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.
Description: 
Fil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: McKee Jr, K. T. Womack Army Medical Center, Fort Bragg, North Carolina; Estados Unidos.

Fil: Barrera Oro, J G. ANLIS Dr.C.G.Malbrán; Argentina.

Fil: Harrison, L H. University of Pittsburgh Graduate School of Public Health,Pittsburgh, Pennsylvania; Estados Unidos.

Fil: Gibbs, P H. Division of Disease Assessment, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701; Estados Unidos.

Fil: Feuillade, María Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Briggiler, Ana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Halsey, N A. Department of International Health, Johns Hopkins Medical Institutions, Baltimore, Maryland; Estados Unidos.

Fil: Peters, C J. Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia; Estados Unidos.
URI: http://sgc.anlis.gob.ar/handle/123456789/2221
ISSN: 0022-1899
DOI: 10.1086/514211
Rights: Open Access
Appears in Collections:Publicaciones INEVH

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