Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/2071
Title: Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis
Authors: González Guerrico, Anatilde M. 
Cafferata, Eduardo 
Radrizzani, Martin 
Marcucci, Florencia 
Gruenert, Dieter 
Pivetta, Omar H. 
Favaloro, Roberto R 
Laguens, Rubén 
Perrone, Sergio V 
Gallo, Guillermo C 
Santa-Coloma, Tomás A. 
Keywords: Tiroxina;Fibrosis Quística
Issue Date: 10-May-2002
Publisher: American Society for Biochemistry and Molecular Biology
Journal: The Journal of biological chemistry 
Abstract: 
Cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) chloride channel, is associated in the respiratory system with the accumulation of mucus and impaired lung function. The role of the CFTR channel in the regulation of the intracellular pathways that determine the overexpression of mucin genes is unknown. Using differential display, we have observed the differential expression of several mRNAs that may correspond to putative CFTR-dependent genes. One of these mRNAs was further characterized, and it corresponds to the tyrosine kinase c-Src. Additional results suggest that c-Src is a central element in the pathway connecting the CFTR channel with MUC1 overexpression and that the overexpression of mucins is a primary response to CFTR malfunction in cystic fibrosis, which occurs even in the absence of bacterial infection.
Description: 
Fil: González Guerrico, Anatilde M. Instituto de Investigaciones Bioquı́micas Fundación Campomar (UBA, CONICET), 1405 Buenos Aires; Argentina.

Fil: Cafferata, Eduardo. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.

Fil: Radrizzani, Martín. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.

Fil: Marcucci, Florencia. Instituto de Investigaciones Bioquı́micas Fundación Campomar (UBA, CONICET), 1405 Buenos Aires; Argentina.

Fil: Gruenert, Dieter. Human Molecular Genetics Unit, Department of Medicine, University of Vermont, Burlington; Estados Unidos.

Fil: Pivetta, Omar H. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.

Fil: Favaloro, Roberto R. Fundación Favaloro, 1093 Buenos Aires; Argentina.

Fil: Laguens, Rubén. Fundación Favaloro, 1093 Buenos Aires; Argentina.

Fil: Perrone, Sergio V. Fundación Favaloro, 1093 Buenos Aires; Argentina.

Fil: Gallo, Guillermo C. Hospital de Pediatrı́a Prof. Dr. Juan P. Garrahan, 1425 Buenos Aires; Argentina.

Fil: Santa-Coloma, Tomás A. Instituto de Investigaciones Bioquı́micas Fundación Campomar (UBA, CONICET), 1405 Buenos Aires; Argentina.
URI: https://www.jbc.org/content/277/19/17239.long
http://sgc.anlis.gob.ar/handle/123456789/2071
ISSN: 0021-9258
DOI: 10.1074/jbc.M112456200
Rights: Open Access
Appears in Collections:Publicaciones CeNaGeM

Files in This Item:
File Description SizeFormat
10.1074_jbc.M112456200.pdfArtículo en inglés886.3 kBAdobe PDFView/Open
Show full item record

Page view(s)

27
checked on Aug 16, 2022

Download(s)

3
checked on Aug 16, 2022

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.