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Título: | Profile of cytokines in the lungs of BALB/c mice after intra-nasal infection with Histoplasma capsulatum mycelial propagules | Autor(es): | Sahaza, Jorge H Suárez-Alvarez, Roberto Estrada-Bárcenas, Daniel Alfonso Pérez-Torres, Armando Taylor, Maria Lucia |
Palavras-chave: | Pulmón;Citocinas;Histoplasma | Data do documento: | Ago-2015 | Editora: | Elsevier | Jornal: | Comparative immunology, microbiology and infectious diseases | Resumo: | The host pulmonary response to the fungus Histoplasma capsulatum was evaluated, through the profile of cytokines detected by the MagPix magnetic beads platform in lung homogenates and by lung-granulomas formation, from mice intra-nasally infected with mycelial propagules (M-phase) of two virulent H. capsulatum strains, EH-46 and G-217B. Results highlight that mice lung inflammatory response depends on the H. capsulatum strain used, during the first step of the fungal infection. IL-1β and TNF-α increased their concentrations in mice infected with both strains. The highest levels of IL-6, IL-17, and IL-23 were found in EH-46-infected mice, whereas levels of IL-22 were variable at all post-infection times for both strains. Significant increases of IL-12, IFN-γ, IL-4, and IL-10 were associated to EH-46-infected mice. Histological lung findings from EH-46-infected mice revealed incipient and numerous well-developed granulomas, distributed in lung-lobes at the 14th and the 21st days after infection, according to cytokine profiles. |
Descrição: | Fil: Sahaza, Jorge H. Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM); México. Fil: Suárez-Alvarez, Roberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Estrada-Bárcenas, Daniel Alfonso. Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM); México. Fil: Pérez-Torres, Armando. Laboratorio de Filogenia del Sistema Inmune de Piel y Mucosas, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM; México. Fil: Taylor, Maria Lucia. Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM); México. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1969 | ISSN: | 0147-9571 | DOI: | 10.1016/j.cimid.2015.05.003 | Direitos: | Closed Access |
Aparece nas Coleções: | Publicaciones INEI |
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