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Title: | Epidemiology of snakebite and use of antivenom in Argentina | Authors: | Dolab, Jorge A. de Roodt, Adolfo R. de Titto, Ernesto Horacio García, Susana Isabel Funes, Raúl F Salomón, Oscar Daniel Chippaux, Jean-Philippe |
Keywords: | Argentina;Bothrops;Crotalus;Serpientes de Coral;Mordeduras de Serpientes;Animales;Antivenenos;Esquema de Medicación;Servicio de Urgencia en Hospital;Femenino;Humanos;Masculino;Estaciones del Año;Encuestas y Cuestionarios;Resultado del Tratamiento;Elapidae | Issue Date: | May-2014 | Publisher: | Oxford University Press | Project: | datasets | Journal: | Transactions of the Royal Society of Tropical Medicine and Hygiene | Abstract: | Background: The incidence and case fatality rate of snakebite in Argentina are poorly known. Methods: The authors used questionnaires provided with antivenoms by the primary manufacturer of anti-venoms in Argentina. Results: A total of 8083 completed questionnaires was collected between 1978 and 1998. The annual incidence of snakebite was 1.8 bites per 100,000 inhabitants, with a high geographical heterogeneity; in the northern provinces of the country, the incidence can exceed 150 snakebites per 100,000 people per year. Bothrops (pit viper) bites predominated, accounting for 96.6% (6720/6957) of envenomations, bites from Crotalus (rattlesnake) accounted for 2.8% (195/6957), and bites from Micrurus (coral snake) for 0.6% (42/6957). Most patients were young men, who were generally bitten during agricultural activities, i.e. while working in the fields. Most snakebites (78.9%, 5852/7419) were to the lower limb, including 58.3% (4322/7419) to the foot. The case fatality rate was <0.04% (3/8083). Most envenomations (90%, 7275/8083) were treated with specific antivenom during the first 4 h after the bite. The median dose of antivenom was two vials for viper bites (Bothrops and Crotalus) and three vials for Micrurus bites. Conclusion: These preliminary results should enable manufacturers to increase the availability of appropriate antivenom and health authorities to improve the management of snakebites where they are most common. |
Description: | Fil: Dolab, Jorge Adrián. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina. Fil: de Roodt, Adolfo Rafael. Universidad de Buenos Aires. Facultad de Medicina. Centro de Patología Experimental y Aplicada. Laboratorio de Toxinopatología; Argentina. Fil: de Titto, Ernesto Horacio. Ministerio de Salud. Dirección Nacional de Determinantes de la Salud e Investigación; Argentina. Fil: García, Susana Isabel. Ministerio de Salud. Dirección Nacional de Determinantes de la Salud e Investigación; Argentina. Fil: Funes, Raúl. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina. Fil: Salomón, Oscar Danie. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Medicina Tropical; Argentina. Fil: Chippaux, Jean-Philippe. Institut de Recherche pour le Développement; Francia. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1866 | DOI: | 10.1093/trstmh/tru038 |
Appears in Collections: | Publicaciones INPB |
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