Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1866
Title: Epidemiology of snakebite and use of antivenom in Argentina
Authors: Dolab, Jorge A. 
de Roodt, Adolfo R. 
de Titto, Ernesto Horacio 
García, Susana Isabel 
Funes, Raúl F 
Salomón, Oscar Daniel 
Chippaux, Jean-Philippe 
Keywords: Argentina;Bothrops;Crotalus;Serpientes de Coral;Mordeduras de Serpientes;Animales;Antivenenos;Esquema de Medicación;Servicio de Urgencia en Hospital;Femenino;Humanos;Masculino;Estaciones del Año;Encuestas y Cuestionarios;Resultado del Tratamiento;Elapidae
Issue Date: May-2014
Publisher: Oxford University Press
Project: datasets
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 
Abstract: 
Background: The incidence and case fatality rate of snakebite in Argentina are poorly known.

Methods: The authors used questionnaires provided with antivenoms by the primary manufacturer of anti-venoms in Argentina.

Results: A total of 8083 completed questionnaires was collected between 1978 and 1998. The annual incidence of snakebite was 1.8 bites per 100,000 inhabitants, with a high geographical heterogeneity; in the northern provinces of the country, the incidence can exceed 150 snakebites per 100,000 people per year. Bothrops (pit viper) bites predominated, accounting for 96.6% (6720/6957) of envenomations, bites from Crotalus (rattlesnake) accounted for 2.8% (195/6957), and bites from Micrurus (coral snake) for 0.6% (42/6957). Most patients were young men, who were generally bitten during agricultural activities, i.e. while working in the fields. Most snakebites (78.9%, 5852/7419) were to the lower limb, including 58.3% (4322/7419) to the foot. The case fatality rate was <0.04% (3/8083). Most envenomations (90%, 7275/8083) were treated with specific antivenom during the first 4 h after the bite. The median dose of antivenom was two vials for viper bites (Bothrops and Crotalus) and three vials for Micrurus bites.

Conclusion: These preliminary results should enable manufacturers to increase the availability of appropriate antivenom and health authorities to improve the management of snakebites where they are most common.
Description: 
Fil: Dolab, Jorge Adrián. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.

Fil: de Roodt, Adolfo Rafael. Universidad de Buenos Aires. Facultad de Medicina. Centro de Patología Experimental y Aplicada. Laboratorio de Toxinopatología; Argentina.

Fil: de Titto, Ernesto Horacio. Ministerio de Salud. Dirección Nacional de Determinantes de la Salud e Investigación; Argentina.

Fil: García, Susana Isabel. Ministerio de Salud. Dirección Nacional de Determinantes de la Salud e Investigación; Argentina.

Fil: Funes, Raúl. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.

Fil: Salomón, Oscar Danie. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Medicina Tropical; Argentina.

Fil: Chippaux, Jean-Philippe. Institut de Recherche pour le Développement; Francia.
URI: http://sgc.anlis.gob.ar/handle/123456789/1866
DOI: 10.1093/trstmh/tru038
Appears in Collections:Publicaciones INPB

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