Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1701
Title: A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
Authors: Colli, Sandra 
Furforo, Lilian 
Rojo Pisarello, Eduardo 
Maidana, Marcela 
Martín, Carlos 
Bordone, Javier 
Slavutsky, Irma 
Keywords: Hibridación Fluorescente in Situ;Leucemia-Linfoma Linfoblástico de Células T Precursoras;Citogenética
Issue Date: Apr-2016
Journal: Cancer genetics 
Abstract: 
Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
Description: 
Fil: Colli, Sandra. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.

Fil: Furforo, Lilian. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.

Fil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.

Fil: Maidana, Marcela. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.

Fil: Martín, Carlos. Consultorio de Hematopatología; La Plata, Argentina.

Fil: Bordone, Javier. Consultorio de Hematopatología; La Plata, Argentina.

Fil: Slavutsky, Irma. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/1701
ISSN: 2210-7762
DOI: 10.1016/j.cancergen.2016.01.001
Rights: Open Access
Creative Commons Attribution 4.0 International Licenses
Appears in Collections:Publicaciones CeNaGeM

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