Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1653
Title: | Citoquinas inducidas por la inmunización experimental antitetánica efecto de la formulación vacunal | Other Titles: | Cytokines induced by experimental anti-tetanus immunization. Vaccine formulation effect | Authors: | Castro, Marisa Mateo, Nancy A Lavigne, Victoria Deluchi, Silvana Atzori, Carlos Piudo, Luciana Brero, María Luisa Manghi, Marcela |
Keywords: | Citocinas;Toxoide Tetánico | Issue Date: | 2002 | Journal: | Medicina (Buenos Aires) | Abstract: | Several factors are involved in the selective activation of T helper 1 or T helper 2 cells, such as the type of antigen-presenting cells involved in the immune response and the different physical characteristics of antigens. The aim of this work was to evaluate if adding other antigens to tetanus toxoid modifies the original immune response. BALB/c mice were immunized with tetanus and diphtheria toxoids associated with whole-cell Bordetella pertussis (DTPw vaccine), B. pertussis soluble antigens (DTPa vaccine) or Salmonella typhi plus DTPa (DTPaSt vaccine). DTPw and DTPaSt immunization induced a T helper 1/T helper 2 (Th1/Th2) anti-tetanus response with gamma interferon and interleukin 5 production. DTPa immunization induced a Th2 response with production of interleukin 5 and interleukin 6. Only DTPw vaccine induced higher levels of IL-12 in non-immunized mice. Our findings indicate that the co-injection of whole-cell antigens such as B. pertussis or S. typhi, modifies the anti-tetanus response shifting it from Th2 to Th1 type. However, the original Th2 immune response is not modified when the vaccine consists only of soluble antigens. |
Description: | Fil: Castro, Marisa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral; Argentina. Fil: Mateo, Nancy A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina. Fil: Lavigne, Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral; Argentina. Fil: Deluchi, Silvana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina. Fil: Atzori, Carlos. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina. Fil: Piudo, Luciana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina. Fil: Brero, María Luisa. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina. Fil: Manghi, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1653 http://www.medicinabuenosaires.com/revistas/vol62-02/2/v62_n2_p154_158.pdf |
ISSN: | 0025-7680 | Rights: | Open Access Creative Commons Attribution 4.0 International License |
Appears in Collections: | Publicaciones CNCCB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
MED_2002_62_154-158.pdf | Artículo en español | 40.87 kB | Adobe PDF | View/Open |
Page view(s)
43
checked on Apr 19, 2024
Download(s)
2
checked on Apr 19, 2024
Google ScholarTM
Check
This item is licensed under a Creative Commons License