Use este identificador para citar ou linkar para este item: http://sgc.anlis.gob.ar/handle/123456789/1642
Título: Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
Autor(es): Pinto, Alipio 
Berdasco, Clara 
Arenas-Mosquera, David 
Cangelosi, Adriana 
Geoghegan, Patricia A. 
Nuñez, Myriam C 
Goldstein, Jorge 
Palavras-chave: Dexametasona;Encefalopatía;Síndrome Hemolítico-Urémico;Inflamación;Neuroprotección
Data do documento: Dez-2018
Jornal: International journal of medical microbiology : IJMM 
Resumo: 
Infections by Enterohemorrhagic Escherichia coli may cause in addition to hemolytic uremic syndrome neurological disorders which may lead to fatal outcomes in patients. The brain striatum is usually affected during this outcome. The aim of this study was to determine in this area the role of the microglia in pro-inflammatory events that may occur during Shiga toxin 2 intoxication and consequently to this, whether oligodendrocytes were being affected. In the present paper we demonstrated that anti-inflammatory treatments reduced deleterious effects in brain striatal cells exposed to Shiga toxin 2 and LPS. While dexamethasone treatment decreased microglial activation and recovered myelin integrity in the mice striatum, etanercept treatment decreased neuronal uptake of Stx2 in rat striatal neurons, improving the affected area from toxin-derived injury. In conclusion, microglial activation is related to pro-inflammatory events that may deteriorate the brain function during intoxication with Stx2 and LPS. Consequently, the role of anti-inflammatory agents in the treatment of EHEC-derived encephalopathy should be studied in clinical trials.
Descrição: 
Fil: Pinto, Alipio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.

Fil: Berdasco, Clara. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.

Fil: Arenas-Mosquera, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.

Fil: Cangelosi, Adriana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.

Fil: Geoghegan, Patricia A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.

Fil: Nuñez, Myriam C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Matemáticas; Argentina.

Fil: Goldstein, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/1642
DOI: 10.1016/j.ijmm.2018.09.007
Aparece nas Coleções:Publicaciones CNCCB

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