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Title: Shiga toxin 2 from enterohemorrhagic Escherichia coli induces reactive glial cells and neurovascular disarrangements including edema and lipid peroxidation in the murine brain hippocampus
Authors: Berdasco, Clara 
Pinto, Alipio 
Calabró, Valeria 
Arenas, David 
Cangelosi, Adriana 
Geoghegan, Patricia A. 
Evelson, Pablo 
Goldstein, Jorge 
Keywords: Encefalopatía;Hipocampo;Peroxidación de Lípido
Issue Date: 7-Feb-2019
Journal: Journal of biomedical science 
Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients. Being a Gram negative bacterium, lipopolysaccharide is also released. Particularly, the hippocampus has been found affected in patients intoxicated with Shiga toxin 2. In the current work, the deleterious effects of Shiga toxin 2 and lipopolysaccharide are investigated in detail in hippocampal cells for the first time in a translational murine model, providing conclusive evidences on how these toxins may damage in the observed clinic cases.
DOI: 10.1186/s12929-019-0509-x
Appears in Collections:Publicaciones CNCCB

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