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Título: | Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient | Autor(es): | Martino, Florencia Tijet, Nathalie Melano, Roberto Petroni, Alejandro Heinz, E De Belder, Denise Faccone, Diego Rapoport, Melina J. Biondi, Estefania Rodrigo, Veronica Vázquez, Miryam Pasteran, Fernando Thomson, Nicholas R Corso, Alejandra Gomez, Sonia A. |
Palavras-chave: | Pediatría;Enterobacteriaceae;Plásmidos | Data do documento: | 9-Ago-2019 | Jornal: | PloS one | Resumo: | In Argentina, NDM metallo-β-lactamase was first reported in 2013. By now, it has disseminated throughout the country in diverse Gram negative bacteria. Here, we report the case of a paediatric patient that underwent a 1-year hospitalisation due to erythrodermic psoriasis in 2014 and received multiple antimicrobial treatments. During his stay, five isolates were obtained from rectal swabs (rs) or blood culture (bc) suspicious of carbapenemase production: a K. quasipneumoniae subsp. quasipneumoniae (rs), Citrobacter freundii (rs), Escherichia coli (bc), Enterobacter cloacae (rs), and a Serratia marcescens (bc). The isolates were studied with broth microdilution, biparental conjugation and plasmid and whole genome sequencing (Illumina). All isolates harboured an 138,998-bp type 1 IncC plasmid that carried blaNDM-1, bleMBL, blaCMY-6, rmtC, aac(6')-Ib, and sul1 resistance genes. Additionally, the blaNDM-plasmids contained ISKpn8 an insertion sequence previously described as associated only to blaKPC. One isolate, a colistin-resistant E. coli, also carried a mcr-1-containing an IncI2 plasmid, which did not harbour additional resistance. The whole genome of K. quasipneumoniae subsp. quasipneumoniae isolate was fully sequenced. This isolate harboured, additionally to blaNDM, three plasmid-mediated quinolone resistance genes: qnrB4, qnrB52 and aac(6')-Ib-cr1. The E. cloacae isolate also harboured qnrA1. These findings alert to the underestimated horizontal dissemination of multidrug-resistant plasmids limiting treatment options with last resort antimicrobials. This research was funded by Agencia Nacional de Promoción Científica y Tecnológica - Fondo para la Investigación Científica y Tecnológica, PICT-2012-0145 to SAG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
Descrição: | Fil: Martino, Florencia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentin Fil: Tijet, Nathalie. Public Health Ontario Laboratories, Toronto, Ontario; Canadá. Fil: Melano, Roberto. Public Health Ontario Laboratories, Toronto, Ontario; Canadá. Fil: Petroni, Alejandro. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina. Fil: Heinz, E. The Welcome Trust Sanger Institute, Hinxton, Cambridge; Reino Unido. Fil: De Belder, Denise. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina. Fil: Faccone, Diego. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina. Fil: Rapoport, Melina J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina. Fil: Biondi, Estefania. Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires; Argentina. Fil: Rodrigo, Veronica. Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires; Argentina. Fil: Vázquez, Miryam. Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires; Argentina. Fil: Pasteran, Fernando. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina. Fil: Thomson, Nicholas R. The Welcome Trust Sanger Institute, Hinxton, Cambridge; Reino Unido. Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina. Fil: Gomez, Sonia A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina. |
URI: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221960 http://sgc.anlis.gob.ar/handle/123456789/1531 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0221960 | Direitos: | Open Access Creative Commons Attribution 4.0 International License |
Aparece nas Coleções: | Publicaciones INEI |
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PLoSOne_2019_14_9_e0221960.pdf | 944.3 kB | Adobe PDF | Ver/Aberto |
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