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Title: | Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies | Authors: | Sguassero, Yanina Cuesta, Cristina B Roberts, Karen N Hicks, Elizabeth Comandé, Daniel Ciapponi, Agustin Sosa-Estani, Sergio |
Issue Date: | 2015 | Journal: | PloS one | Abstract: | Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi (T. cruzi). It is endemic in Latin American countries outside the Caribbean. The current criterion for cure in the chronic phase of the disease is the negativization of at least two serological tests such as enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence assay (IIF) and indirect hemagglutination assay (IHA). The serological evolution of treated subjects with chronic T. cruzi infection is variable. Treatment failure is indicated by a positive parasitological and/or molecular test (persistence of parasitemia). |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1472 | DOI: | 10.1371/journal.pone.0139363 |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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pone.0139363.pdf | Artículo en inglés | 2.77 MB | Adobe PDF | View/Open |
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