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Title: Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies
Authors: Sguassero, Yanina 
Cuesta, Cristina B 
Roberts, Karen N 
Hicks, Elizabeth 
Comandé, Daniel 
Ciapponi, Agustin 
Sosa-Estani, Sergio 
Issue Date: 2015
Journal: PloS one 
Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi (T. cruzi). It is endemic in Latin American countries outside the Caribbean. The current criterion for cure in the chronic phase of the disease is the negativization of at least two serological tests such as enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence assay (IIF) and indirect hemagglutination assay (IHA). The serological evolution of treated subjects with chronic T. cruzi infection is variable. Treatment failure is indicated by a positive parasitological and/or molecular test (persistence of parasitemia).
DOI: 10.1371/journal.pone.0139363
Appears in Collections:Publicaciones INP

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