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http://sgc.anlis.gob.ar/handle/123456789/1418| Title: | Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis | Authors: | Natale, María A Cesar, Gonzalo Alvarez, María G Castro Eiro, Melisa D Lococo, Bruno Bertocchi, Graciela Albareda, María Cecilia Laucella, Susana A. |
Keywords: | Enfermedad de Chagas;Trypanosoma cruzi | Issue Date: | 5-Dec-2018 | Publisher: | Yes | Journal: | PLoS neglected tropical diseases | Abstract: | The severity of cardiac disease in chronic Chagas disease patients is associated with different features of T-cell exhaustion. Here, we assessed whether the ability of T cells to secrete IFN-γ in response to T. cruzi was linked to disruption in immune homeostasis and inflammation in patients with chronic Chagas disease. |
Description: | Fil: Natale, María A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Cesar, Gonzalo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina. Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina. Fil: Bertocchi, Graciela. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina. Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1418 | ISSN: | 1935-2735 | DOI: | 10.1371/journal.pntd.0006998 | Rights: | Open Access |
| Appears in Collections: | Publicaciones INP |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| pntd.0006998.pdf | Artículo en inglés | 4.21 MB | Adobe PDF |  View/Open |
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