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Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/536
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dc.contributor.authorViotti, Rodolfo
dc.contributor.authorVigliano, Carlos
dc.contributor.authorAlvarez, María Gabriela
dc.contributor.authorLococo, Bruno
dc.contributor.authorPetti, Marcos
dc.contributor.authorBertochi, Graciela
dc.contributor.authorArmenti, Alejandro
dc.contributor.authorDe Rissio, Ana María
dc.contributor.authorCooley, Gretchen
dc.contributor.authorTarleton, Rick
dc.contributor.authorLaucella, Susana A.
dc.date.accessioned2013-08-01T01:04:18Z-
dc.date.available2013-08-01T01:04:18Z-
dc.date.issued2011-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/536-
dc.descriptionThe main criterion for treatment effectiveness in Chagas Disease has been the seronegative conversion of previously reactive serology, generally achieved many years post-treatment. The lack of reliable tests to ensure parasite clearance and to examine the effect of treatment is the main difficulty in evaluating treatment for chronic Chagas disease. Decreases of conventional and non-conventional serological titers can be useful tools to monitor the early impact of treatment. We serially measured changes in antibody levels, including seronegative conversion as well as declines in titers in 53 benznidazole-treated and 89 untreated chronically T. cruzi-infected subjects. Seronegative conversion as well as decreases of titers was significantly higher in treated compared with untreated patients. A strong concordance was found between decreases of titers of conventional and non-conventional serologic tests post-treatment, reaffirming the findings. When seronegative conversion plus decreases of titers were considered altogether, the impact of treatment was higher, in a shorter follow-up period than previously considered. New tools for monitoring the effectiveness of treatment of chronic Chagas disease are necessary, and the results showed in this study is a contribution to researchers and physicians who assist patients suffering from this disease.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.sourcePLoS Neglected Tropical Diseases, 2011, 5(9).en_US
dc.titleImpact of aetiological treatment on conventional and multiplex serology in chronic Chagas diseaseen_US
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
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