Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/534
DC Field | Value | Language |
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dc.contributor.author | Acosta, Diana M | es |
dc.contributor.author | Soprano, Luciana L | es |
dc.contributor.author | Ferrero, Maximiliano R | es |
dc.contributor.author | Landoni, Malena | es |
dc.contributor.author | Esteva, Monica I | es |
dc.contributor.author | Couto, Alicia S | es |
dc.contributor.author | Duschak, Vilma G | es |
dc.date.accessioned | 2013-07-31T02:42:52Z | - |
dc.date.available | 2013-07-31T02:42:52Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/534 | - |
dc.description | Fil: Acosta, D. M. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina. | es |
dc.description | Fil: Soprano, L. L. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina. | es |
dc.description | Fil: Ferrero, M. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina. | es |
dc.description | Fil: Landoni, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica. Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR); Argentina. | es |
dc.description | Fil: Esteva, Mónica Inés. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina. | es |
dc.description | Fil: Couto, A. S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica. Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR); Argentina. | es |
dc.description | Fil: Duschak, V. G. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina. | es |
dc.description.abstract | Single units of O-linked N-acetylglucosamine (GlcNAc), usually components of nuclear and cytoplasmatic proteins, are present at the C-terminal domain of cruzipain (Cz), a lysosomal major antigen from Trypanosoma cruzi. On the other hand, antibodies directed against some self-antigens like myosin are associated with Chagas heart disease. The participation of O-GlcNAc moieties in the molecular antigenicity of Cz was determined using GlcNAc linked to aprotinin by ELISA. The immune cross-reactivity between Cz and myosin is mainly focused in the C-T domain. ELISA inhibition assays using rabbit sera specific for Cz and C-T in conjunction with immune-gold electron microscopy analysis of heart tissues from mice immunized with C-T confronted with polyclonal rabbit sera specific for Cz and C-T prior and after myosin adsorption provided evidence which indicates that O-GlcNAc moieties constitute a common epitope between Cz and either myosin or other cardiac O-GlcNAc-containing proteins, showing a new insight into the molecular immune pathogenesis of Chagas heart disease. | es |
dc.format | - | |
dc.language.iso | en | es |
dc.relation.ispartof | Parasite immunology | es |
dc.relation.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Creative Commons Attribution 4.0 International License | - |
dc.source | Parasite immunology, 2011, 33(7), 363-370. | en_US |
dc.subject | Enfermedad de Chagas | es |
dc.subject | Miosina | es |
dc.subject | Trypanosoma cruzi | es |
dc.title | A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1111/j.1365-3024.2011.01291.x | - |
anlis.essnrd | 1 | - |
item.openairetype | Artículo | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Preproducción Publicaciones INP |
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Parasiteimmunology,2011,33(7),363-370..pdf | 668.58 kB | Adobe PDF | View/Open |
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