Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/534
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dc.contributor.authorAcosta, Diana Mes
dc.contributor.authorSoprano, Luciana Les
dc.contributor.authorFerrero, Maximiliano Res
dc.contributor.authorLandoni, Malenaes
dc.contributor.authorEsteva, Monica Ies
dc.contributor.authorCouto, Alicia Ses
dc.contributor.authorDuschak, Vilma Ges
dc.date.accessioned2013-07-31T02:42:52Z-
dc.date.available2013-07-31T02:42:52Z-
dc.date.issued2011-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/534-
dc.descriptionFil: Acosta, D. M. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina.es
dc.descriptionFil: Soprano, L. L. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina.es
dc.descriptionFil: Ferrero, M. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina.es
dc.descriptionFil: Landoni, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica. Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR); Argentina.es
dc.descriptionFil: Esteva, Mónica Inés. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina.es
dc.descriptionFil: Couto, A. S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica. Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR); Argentina.es
dc.descriptionFil: Duschak, V. G. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (INP); Argentina.es
dc.description.abstractSingle units of O-linked N-acetylglucosamine (GlcNAc), usually components of nuclear and cytoplasmatic proteins, are present at the C-terminal domain of cruzipain (Cz), a lysosomal major antigen from Trypanosoma cruzi. On the other hand, antibodies directed against some self-antigens like myosin are associated with Chagas heart disease. The participation of O-GlcNAc moieties in the molecular antigenicity of Cz was determined using GlcNAc linked to aprotinin by ELISA. The immune cross-reactivity between Cz and myosin is mainly focused in the C-T domain. ELISA inhibition assays using rabbit sera specific for Cz and C-T in conjunction with immune-gold electron microscopy analysis of heart tissues from mice immunized with C-T confronted with polyclonal rabbit sera specific for Cz and C-T prior and after myosin adsorption provided evidence which indicates that O-GlcNAc moieties constitute a common epitope between Cz and either myosin or other cardiac O-GlcNAc-containing proteins, showing a new insight into the molecular immune pathogenesis of Chagas heart disease.es
dc.formatPDF-
dc.language.isoenes
dc.relation.ispartofParasite immunologyes
dc.relation.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsCreative Commons Attribution 4.0 International License-
dc.sourceParasite immunology, 2011, 33(7), 363-370.en_US
dc.subjectEnfermedad de Chagases
dc.subjectMiosinaes
dc.subjectTrypanosoma cruzies
dc.titleA striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosines
dc.typeArtículoes
dc.identifier.doi10.1111/j.1365-3024.2011.01291.x-
anlis.essnrd1-
item.openairetypeArtículo-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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