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Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/494
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dc.contributor.authorRojas, Paola A.
dc.contributor.authorMartin, Valentina
dc.contributor.authorNigro, Monica
dc.contributor.authorEcheverria, Pablo C.
dc.contributor.authorGuarnera, Eduardo
dc.contributor.authorPszenny, Viviana
dc.contributor.authorAngel, Sergio O.
dc.date.accessioned2013-05-22T16:55:18Z
dc.date.available2013-05-22T16:55:18Z
dc.date.issued2000
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/494
dc.descriptionA cDNA clone (Tgzy85d11.r1) obtained from the Toxoplasma Expressed Sequence Tag project was chosen due to its homology with proteins of the heat shock 90 family. The cDNA encodes 137 amino acids of the C-terminal portion of the Toxoplasma Hsp90 protein (TgHsp90). Serum samples obtained from orally infected BALB/c and C57BL/6 mice showed reactivity against a recombinant TgHsp90 (rTgHsp90) after 8 weeks postinfection. Isotype analysis showed an anti-rTgHsp90 IgG2a/IgG3 response in infected BALB/c and antirTgHsp90 IgG1/IgG2a/IgG2b response in infected C57BL/6 mice. Serum samples from individuals chronically and putative acutely infected with T. gondii showed a similar anti-rTgHsp90 IgG response. Our work identifies TgHsp90 as a novel parasite antigen that seems to elicit a higher relation of anti-TgHsp90/anti-T. gondii IgGs during chronic infection in comparison with the acute stage.en_US
dc.rightsrestrictedAccessen_US
dc.sourceFEMS Microbiology Letters, 2000, 190(2), 209-213.en_US
dc.titleExpression of a cDNA encoding a Toxoplasma gondii protein belonging to the heat-shock 90 family and analysis of its antigenicityen_US
item.grantfulltextopen-
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crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Parasitología (INP)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
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