Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/475| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Martin, Diana L. | |
| dc.contributor.author | Postan, Miriam | |
| dc.contributor.author | Lucas, Philip | |
| dc.contributor.author | Gress, Ronald | |
| dc.contributor.author | Tarleton, Rick | |
| dc.date.accessioned | 2013-04-12T23:59:28Z | - |
| dc.date.available | 2013-04-12T23:59:28Z | - |
| dc.date.issued | 2007 | - |
| dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/475 | - |
| dc.description | Infection with the protozoan parasite Trypanosoma cruzi leads to chronic infection, with parasite persistence primarily in muscle tissue. CD8(+) T cells isolated from muscle tissue of T. cruzi-infected mice display decreased production of IFN-gamma in response to T cell receptor engagement. The expression of TGF-beta at the site of CD8(+) T cell dysfunction and parasite persistence suggested that this immunoregulatory cytokine might play a role in these processes. Mice expressing a T cell-specific dominant negative TGF-beta receptor type II (DNRII) were therefore infected with T. cruzi. Infection of DNRII mice resulted in massive CD8(+) T cell proliferation, leading to increased numbers but decreased frequencies of antigen-specific CD8(+) T cells in the spleen compared to wild-type mice. However, TGF-beta unresponsiveness failed to restore effector functions of CD8(+) T cells isolated from muscle tissue. Histological examination of skeletal muscle from T. cruzi-infected DNRII mice revealed an extensive cellular infiltrate, and DNRII mice displayed higher susceptibility to infection. Overall, while TGF-beta does not appear to be responsible for CD8(+) T cell unresponsiveness in peripheral tissue in T. cruzi-infected mice, these data suggest a role for TGF-beta in control of immunopathology in response to T. cruzi infection. | en_US |
| dc.rights | closedAccess | en_US |
| dc.source | European journal of immunology, 2007, 37(10), 2764-2771. | en_US |
| dc.title | TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection | en_US |
| item.grantfulltext | open | - |
| item.fulltext | With Fulltext | - |
| Appears in Collections: | Preproducción Publicaciones INP | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Europeanjournalofimmunology,2007,37(10),2764-2771..pdf | 247.27 kB | Adobe PDF |  View/Open | |
| Eur.J.Immunol.2007.37,3605 -Correccion.pdf | 47 kB | Adobe PDF |  View/Open |
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